ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005887
Name integral to plasma membrane
Type Cellular Component
No. of Genes in ADHDgene  220
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 220)

Literature-origin genes (count: 63)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) IC[2531656]; IDA[8413587]
GPC6 glypican 6 13q32 1(0/0/1) TAS[10329016]
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0) TAS[1718258]
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 7q36 1(0/0/1) TAS[8798755]
GPC5 glypican 5 13q32 1(0/0/1) TAS[7657705]
OXTR oxytocin receptor 3p25 1(0/1/0) TAS[10858434]
CALY calcyon neuron-specific vesicular protein 10q26.3 2(1/1/0) IDA[14534309]
GRM8 glutamate receptor, metabotropic 8 7q31.3-q32.1 1(1/0/0) TAS[9473604]
GRM7 glutamate receptor, metabotropic 7 3p26-p25 1(1/0/0) NAS[9473604]
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0) IC[2144334]
EREG epiregulin 4q21.21 1(0/0/1) TAS[9337852]
DCLK1 doublecortin-like kinase 1 13q13.3 1(1/0/0) TAS[10036192]
DRD4 dopamine receptor D4 11p15.5 67(49/18/0) IDA[15755724]
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) IC[8301582]; IDA[8413587]
BMPR1B bone morphogenetic protein receptor, type IB 4q23-q24 1(0/0/1) IC[14523231]
FADS2 fatty acid desaturase 2 11q12.2 3(3/0/0) TAS[9867867]
PTPRG protein tyrosine phosphatase, receptor type, G 3p21-p14 1(0/0/1) TAS[8382771]
GPR50 G protein-coupled receptor 50 Xq28 1(0/0/1) TAS[8647286]
PTPRJ protein tyrosine phosphatase, receptor type, J 11p11.2 1(0/1/0) TAS[7937872]
ADRA1A adrenergic, alpha-1A-, receptor 8p21.2 3(2/1/0) TAS[8396931]
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 6p21.3 2(1/1/0) TAS[3456344]
GRID2 glutamate receptor, ionotropic, delta 2 4q22 1(0/0/1) TAS[9465309]
SLC7A10 solute carrier family 7, (neutral amino acid transporter, y+ system) member 10 19q13.1 1(1/0/0) NAS[10863037]
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 10q21-q24 1(0/1/0) TAS[8226867]
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1) TAS[8260617]
HTR6 5-hydroxytryptamine (serotonin) receptor 6 1p36-p35 2(0/2/0) TAS[8522988]
ADRA2A adrenergic, alpha-2A-, receptor 10q24-q26 12(4/8/0) IDA[10948191]
GRIK4 glutamate receptor, ionotropic, kainate 4 11q 1(0/1/0) TAS[8263508]
ADRA1D adrenergic, alpha-1D-, receptor 20p13 1(0/1/0) TAS[7746284]
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A 7q36.1 1(0/1/0) TAS[7988681]
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17pter-p12 2(0/2/0) TAS[1976629]
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0) IDA[15494731]
ADRA1B adrenergic, alpha-1B-, receptor 5q33.3 2(1/1/0) TAS[1328250]
HTR4 5-hydroxytryptamine (serotonin) receptor 4 5q31-q33 1(1/0/0) TAS[9276448]
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0) TAS[8768735]
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B 11q23.1 3(1/2/0)
SLC18A2 solute carrier family 18 (vesicular monoamine), member 2 10q25 2(0/2/0) TAS[8095030]
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A 11q23.1-q23.2 1(0/1/0) TAS[7565620]
ADRA2C adrenergic, alpha-2C-, receptor 4p16.3 7(2/4/1) IDA[16605244]
DRD5 dopamine receptor D5 4p16.1 22(14/6/2) NAS[1826762]; TAS[9457173]
ADRA2B adrenergic, alpha-2B-, receptor 2q11.1 1(1/0/0) TAS[2164221]
HAS3 hyaluronan synthase 3 16q22.1 1(0/0/1) TAS[9169154]
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 17q11.2 25(13/12/0) IC[19270731]
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13q14-q21 12(6/6/0) TAS[9109547]
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E 6q14-q15 2(2/0/0) TAS[1733778]
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1) TAS[7568007]
MTNR1A melatonin receptor 1A 4q35 1(1/0/0) IDA[10531408]
NRXN1 neurexin 1 2p16.3 1(0/1/0) TAS[1621094]
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F 3p12 1(0/1/0) TAS[8380639]
SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 3p25-p24 1(0/1/0)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D 1p36.3-p34.3 2(1/1/0) TAS[1652050]
ADRB1 adrenergic, beta-1-, receptor 10q24-q26 2(0/2/0) TAS[10212248]
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0) TAS[7476890]
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 6q13 13(5/8/0) TAS[1559993]
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 16q12.2 16(10/5/1)
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1) TAS[7908515]
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5p15.3 68(42/25/1)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A 5q11.2-q13 1(1/0/0) TAS[3138543]
ADRB3 adrenergic, beta-3-, receptor 8p12 2(0/2/0) TAS[1718744]
OPRM1 opioid receptor, mu 1 6q24-q25 1(1/0/0) TAS[7905839]
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 1(1/0/0) TAS[8768735]
ADRB2 adrenergic, beta-2-, receptor, surface 5q31-q32 2(1/1/0) IDA[12297500]
MMP24 matrix metallopeptidase 24 (membrane-inserted) 20q11.2 1(0/0/1) TAS[10363975]

Genes from other sources Help (count: 157)

Approved Symbol Approved Name Source Evidence[PMID]
ADAM8 ADAM metallopeptidase domain 8 Mapped by CNV; Mapped by LD-proxy IDA[18397961]
PTPRK protein tyrosine phosphatase, receptor type, K Mapped by CNV; Mapped by significant region NAS[9047348]
RXFP3 relaxin/insulin-like family peptide receptor 3 Mapped by significant region TAS[10806363]
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 Mapped by PBA pathway TAS[10613843]
GPNMB glycoprotein (transmembrane) nmb Mapped by CNV; Mapped by significant region
CCKBR cholecystokinin B receptor Mapped by CNV; Mapped by PBA pathway IC[10913157]
CXCR5 chemokine (C-X-C motif) receptor 5 Mapped by significant region TAS[1425907]
FLT4 fms-related tyrosine kinase 4 Mapped by CNV
SLC43A1 solute carrier family 43, member 1 Mapped by significant region TAS[12930836]
STX1B syntaxin 1B Mapped by CNV TAS[8105537]
IGSF6 immunoglobulin superfamily, member 6 Mapped by significant region TAS[9809579]
FLRT3 fibronectin leucine rich transmembrane protein 3 Mapped by CNV NAS[10644439]
TACR3 tachykinin receptor 3 Mapped by CNV TAS[1374246]
FLRT1 fibronectin leucine rich transmembrane protein 1 Mapped by significant region NAS[10644439]
EPHA5 EPH receptor A5 Mapped by CNV; Mapped by significant region
CCKAR cholecystokinin A receptor Mapped by CNV TAS[8343165]
PTPRN protein tyrosine phosphatase, receptor type, N Mapped by significant region TAS[8024693]
CXCR2 chemokine (C-X-C motif) receptor 2 Mapped by significant region TAS[10438939]
SLC39A6 solute carrier family 39 (zinc transporter), member 6 Mapped by significant region IDA[15642354]
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 Mapped by significant region TAS[9344668]
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway TAS[2298749]
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 Mapped by significant region TAS[10329006]
KIAA1324 KIAA1324 Mapped by CNV
GP1BB glycoprotein Ib (platelet), beta polypeptide Mapped by CNV NAS[3353370]
CDHR1 cadherin-related family member 1 Mapped by CNV
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 Mapped by CNV; Mapped by significant region IDA[10525055]
CDH4 cadherin 4, type 1, R-cadherin (retinal) Mapped by CNV
VSIG2 V-set and immunoglobulin domain containing 2 Mapped by significant region TAS[9862345]
LPAR1 lysophosphatidic acid receptor 1 Mapped by significant region TAS[9070858]
EPHA6 EPH receptor A6 Mapped by CNV
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region IDA[8876214]
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 Mapped by significant region TAS[9872942]
TAAR5 trace amine associated receptor 5 Mapped by significant region TAS[9464258]
SLC34A2 solute carrier family 34 (sodium phosphate), member 2 Mapped by CNV NAS[10329428]
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B Mapped by significant region
SLC31A2 solute carrier family 31 (copper transporters), member 2 Mapped by significant region TAS[9207117]
SLC31A1 solute carrier family 31 (copper transporters), member 1 Mapped by significant region TAS[9207117]
PCDH7 protocadherin 7 Mapped by CNV TAS[9615233]
SLC30A5 solute carrier family 30 (zinc transporter), member 5 Mapped by significant region TAS[11937503]
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 Mapped by significant region NAS[18397322]
DCBLD2 discoidin, CUB and LCCL domain containing 2 Mapped by CNV IDA[11447234]
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS[7568191]
NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) Mapped by significant region IC[1660465]
SPN sialophorin Mapped by CNV
AQP4 aquaporin 4 Mapped by significant region
EDA2R ectodysplasin A2 receptor Mapped by CNV
CCR5 chemokine (C-C motif) receptor 5 Mapped by PBA pathway TAS[10393923]
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 Mapped by CNV; Mapped by literature SNP
S1PR3 sphingosine-1-phosphate receptor 3 Mapped by significant region TAS[9409733]
IFNGR1 interferon gamma receptor 1 Mapped by significant region TAS[2971451]
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 Mapped by significant region TAS[8391931]
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 Mapped by significant region
ORAI1 ORAI calcium release-activated calcium modulator 1 Mapped by PBA pathway IDA[16645049]
NEU3 sialidase 3 (membrane sialidase) Mapped by significant region TAS[10405317]
EDNRA endothelin receptor type A Mapped by PBA pathway TAS[1326535]
APLNR apelin receptor Mapped by significant region TAS[8294032]
LIFR leukemia inhibitory factor receptor alpha Mapped by significant region TAS[1915266]
TLR4 toll-like receptor 4 Mapped by significant region IDA[15027902]
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mapped by CNV; Mapped by significant region
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 Mapped by CNV TAS[9278324]
ADORA2A adenosine A2a receptor Mapped by CNV TAS[8794889]
SLC29A2 solute carrier family 29 (nucleoside transporters), member 2 Mapped by significant region TAS[7639753]
GPRC5C G protein-coupled receptor, family C, group 5, member C Mapped by CNV TAS[10783259]
PTPRD protein tyrosine phosphatase, receptor type, D Mapped by CNV TAS[7896816]
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) Mapped by PBA pathway IDA[9211930]
CD300C CD300c molecule Mapped by CNV TAS[1349532]
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway TAS[3443095]
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by PBA pathway; Mapped by significant region TAS[9806836]
GPR52 G protein-coupled receptor 52 Mapped by significant region TAS[9931487]
CHRM1 cholinergic receptor, muscarinic 1 Mapped by PBA pathway; Mapped by significant region TAS[8508928]
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway TAS[10493832]
CHRM5 cholinergic receptor, muscarinic 5 Mapped by CNV; Mapped by PBA pathway TAS[3272174]
BACE1 beta-site APP-cleaving enzyme 1 Mapped by significant region IDA[12586838]
GPR21 G protein-coupled receptor 21 Mapped by significant region TAS[9073069]
CD3E CD3e molecule, epsilon (CD3-TCR complex) Mapped by significant region NAS[9485181]
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway IDA[9368034]
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 Mapped by significant region IDA[14749323]
TM7SF2 transmembrane 7 superfamily member 2 Mapped by significant region TAS[9878250]
MEP1B meprin A, beta Mapped by significant region TAS[9288916]
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 Mapped by significant region IDA[10660625]
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 Mapped by CNV TAS[9242461]
PRKD1 protein kinase D1 Mapped by significant region TAS[8119958]
SCARB1 scavenger receptor class B, member 1 Mapped by CNV
GJA1 gap junction protein, alpha 1, 43kDa Mapped by significant region TAS[15709751]
RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) Mapped by significant region TAS[10085068]
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Mapped by significant region TAS[10328880]
CASR calcium-sensing receptor Mapped by PBA pathway TAS[7759551]
STAB2 stabilin 2 Mapped by LD-proxy IDA[12077138]
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 Mapped by significant region TAS[1535625]
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 Mapped by significant region TAS[9221902]
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 Mapped by CNV; Mapped by significant region TAS[1321750]
SLCO1B3 solute carrier organic anion transporter family, member 1B3 Mapped by LD-proxy TAS[10779507]
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) Mapped by PBA pathway; Mapped by significant region
LRRC32 leucine rich repeat containing 32 Mapped by significant region TAS[8180135]
F2RL2 coagulation factor II (thrombin) receptor-like 2 Mapped by PBA pathway TAS[9087410]
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 Mapped by CNV; Mapped by significant region TAS[1664410]
XPR1 xenotropic and polytropic retrovirus receptor 1 Mapped by significant region TAS[9927670]
C9 complement component 9 Mapped by significant region TAS[2426252]
TRPM2 transient receptor potential cation channel, subfamily M, member 2 Mapped by PBA pathway TAS[9806837]
CD5 CD5 molecule Mapped by significant region NAS[1711157]
CD6 CD6 molecule Mapped by significant region TAS[1919444]
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway TAS[9349813]
BDKRB2 bradykinin receptor B2 Mapped by PBA pathway TAS[7916737]
NPC1 Niemann-Pick disease, type C1 Mapped by significant region IDA[10821832]
TMEM11 transmembrane protein 11 Mapped by significant region NAS[2110658]
GJA8 gap junction protein, alpha 8, 50kDa Mapped by CNV TAS[7796604]
ST14 suppression of tumorigenicity 14 (colon carcinoma) Mapped by significant region TAS[10831593]
TRPV2 transient receptor potential cation channel, subfamily V, member 2 Mapped by significant region TAS[10201375]
CD3G CD3g molecule, gamma (CD3-TCR complex) Mapped by significant region NAS[9485181]
NTSR2 neurotensin receptor 2 Mapped by significant region TAS[9851594]
LTB4R2 leukotriene B4 receptor 2 Mapped by significant region TAS[10913346]
TRPV5 transient receptor potential cation channel, subfamily V, member 5 Mapped by PBA pathway IDA[15489237]
LTB4R leukotriene B4 receptor Mapped by significant region TAS[9177352]
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 Mapped by significant region TAS[8159738]
TRPV6 transient receptor potential cation channel, subfamily V, member 6 Mapped by PBA pathway TAS[11278579]
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 Mapped by significant region TAS[8670200]
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) Mapped by significant region TAS[7989337]
GJA5 gap junction protein, alpha 5, 40kDa Mapped by CNV
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Mapped by PBA pathway TAS[9520418]
GNRHR gonadotropin-releasing hormone receptor Mapped by significant region TAS[8386108]
CHRNB4 cholinergic receptor, nicotinic, beta 4 Mapped by LD-proxy IC[11742001]
STOM stomatin Mapped by significant region IDA[1547348]
UPK2 uroplakin 2 Mapped by significant region TAS[8175808]
NLGN1 neuroligin 1 Mapped by CNV
ROM1 retinal outer segment membrane protein 1 Mapped by significant region TAS[1610568]
FOLR1 folate receptor 1 (adult) Mapped by significant region TAS[10633085]
MC5R melanocortin 5 receptor Mapped by CNV TAS[7739752]
ROR2 receptor tyrosine kinase-like orphan receptor 2 Mapped by significant region TAS[1334494]
IL11RA interleukin 11 receptor, alpha Mapped by LD-proxy TAS[7670098]
SCNN1G sodium channel, nonvoltage-gated 1, gamma Mapped by significant region TAS[8640238]
C3AR1 complement component 3a receptor 1 Mapped by PBA pathway TAS[8702752]
GRM6 glutamate receptor, metabotropic 6 Mapped by CNV TAS[9215706]
SORL1 sortilin-related receptor, L(DLR class) A repeats containing Mapped by significant region TAS[9157966]
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 Mapped by significant region NAS[8537108]
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) Mapped by CNV TAS[9175632]
CACNB2 calcium channel, voltage-dependent, beta 2 subunit Mapped by PBA pathway NAS[9594024]
OPCML opioid binding protein/cell adhesion molecule-like Mapped by LD-proxy; Mapped by significant region TAS[1333602]
TMPRSS11A transmembrane protease, serine 11A Mapped by significant region
TMPRSS11D transmembrane protease, serine 11D Mapped by significant region
SCTR secretin receptor Mapped by LD-proxy TAS[7612008]
TRHDE thyrotropin-releasing hormone degrading enzyme Mapped by LD-proxy TAS[10491199]
FZD4 frizzled family receptor 4 Mapped by significant region IC[17955262]
TMPRSS11B transmembrane protease, serine 11B Mapped by significant region
ATRN attractin Mapped by CNV TAS[10086356]
TMPRSS11E transmembrane protease, serine 11E Mapped by significant region
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Mapped by significant region TAS[9571181]
TMPRSS11F transmembrane protease, serine 11F Mapped by significant region
PERP PERP, TP53 apoptosis effector Mapped by significant region
MMP16 matrix metallopeptidase 16 (membrane-inserted) Mapped by CNV TAS[7559440]
SIGMAR1 sigma non-opioid intracellular receptor 1 Mapped by LD-proxy TAS[8954936]
MUSK muscle, skeletal, receptor tyrosine kinase Mapped by significant region
THY1 Thy-1 cell surface antigen Mapped by significant region TAS[2864289]
GHR growth hormone receptor Mapped by CNV; Mapped by significant region IDA[8137822]
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region IDA[17786981]
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 Mapped by significant region NAS[12880872]
SLC4A3 solute carrier family 4, anion exchanger, member 3 Mapped by significant region TAS[7923606]

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Last update: Feb 26, 2014