ADHDgene Database

Gene Report

Basic Info

Approved Symbol	EDA2R
Symbol Alias	XEDAR, EDA-A2R, EDAA2R, TNFRSF27
Approved Name	ectodysplasin A2 receptor
Location	Xq11.1
Position	chrX:65815479-65858883, -
External Links	HGNC: 17756 Entrez Gene: 60401 Ensembl: ENSG00000131080 UCSC: uc004dwq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_12	chrX:65400000-65600000 (NCBI Build 35 (hg17))	200000	Xq12	Duplication	Not determined

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005031	tumor necrosis factor-activated receptor activity	Molecular Function	NAS[11039935]	2
GO:0004872	receptor activity	Molecular Function	IDA[11039935]	36
GO:0009790	embryo development	Biological Process	NAS[12270937]	17
GO:0008544	epidermis development	Biological Process	NAS[11039935]	12
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0005515	protein binding	Molecular Function	IPI[11039935]	910
GO:0046330	positive regulation of JNK cascade	Biological Process	IDA[12270937]	12
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	NAS[11039935]	6
GO:0030154	cell differentiation	Biological Process		51
GO:0016021	integral to membrane	Cellular Component	IC[12270937]	845
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA[11039935]	27

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...

Genes shared at least 5 GO terms with EDA2R (count: 2)

Gene Symbol	Pathway Count	Pathway List
TNFRSF11A	6	tumor necrosis factor-activated receptor activity; receptor activity; protein binding; tumor necrosis factor-mediated signaling pathway; integral to membrane; positive regulation of NF-kappaB transcription factor activity;
TLR4	5	receptor activity; integral to plasma membrane; protein binding; positive regulation of JNK cascade; positive regulation of NF-kappaB transcription factor activity;

Genes shared at least 2 KEGG pathways with EDA2R (count: 0)

View in gBrowse

Region: chrX:65815479..65858883 View in gBrowse