ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SCTR
Approved Name	secretin receptor
Location	2q14.1
Position	chr2:120197419-120282070, -
External Links	HGNC: 10608 Entrez Gene: 6344 Ensembl: ENSG00000080293 UCSC: uc002tma.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs2587686	Chr2:120285695(Fwd)	upstream_gene_variant
rs1992248	Chr2:120283173(Fwd)	upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7612008]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007586	digestion	Biological Process	TAS[7612008]	13
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[7612008]	72
GO:0015055	secretin receptor activity	Molecular Function	TAS[7612008]	1
GO:0007588	excretion	Biological Process	TAS[7612008]	10

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04972	Pancreatic secretion	30	The pancreas performs both exocrine and endocrine functions....... The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion. More...
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...

Genes shared at least 5 GO terms with SCTR (count: 0)

Genes shared at least 2 KEGG pathways with SCTR (count: 6)

Gene Symbol	Pathway Count	Pathway List
CCKAR	2	Neuroactive ligand-receptor interaction; Pancreatic secretion;
CHRM3	2	Neuroactive ligand-receptor interaction; Pancreatic secretion;
ADCY4	2	Pancreatic secretion; Bile secretion;
CA2	2	Pancreatic secretion; Bile secretion;
FXYD2	2	Pancreatic secretion; Bile secretion;
SLC4A2	2	Pancreatic secretion; Bile secretion;

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Region: chr2:120197419..120282070 View in gBrowse