ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GNRHR
Previous Symbol	GRHR
Symbol Alias	LHRHR
Approved Name	gonadotropin-releasing hormone receptor
Location	4q21.2
Position	chr4:68603093-68621804, -
External Links	HGNC: 4421 Entrez Gene: 2798 Ensembl: ENSG00000109163 UCSC: uc003hdn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
4q13.2	chr4:66600000-70500000	1 (1/0/0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004968	gonadotropin-releasing hormone receptor activity	Molecular Function		1
GO:0016020	membrane	Cellular Component	TAS[9259321]	139
GO:0097211	cellular response to gonadotropin-releasing hormone	Biological Process	TAS[8386108]	1
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8386108]	220
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8386108]	72
GO:0007275	multicellular organismal development	Biological Process	TAS[10686191]	71

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04912	GnRH signaling pathway	28	Gonadotropin-releasing hormone (GnRH) secretion from the hyp...... Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes. More...

Genes shared at least 5 GO terms with GNRHR (count: 0)

Genes shared at least 2 KEGG pathways with GNRHR (count: 0)

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Region: chr4:68603093..68621804 View in gBrowse