ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MTNR1A
Symbol Alias	MEL-1A-R
Approved Name	melatonin receptor 1A
Location	4q35
Position	chr4:187347700-187476721, -
External Links	HGNC: 7463 Entrez Gene: 4543 Ensembl: ENSG00000168412 UCSC: uc003izd.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Chaste P, 2011	One stop mutation in MTNR1A (Y170X) was found and was detected exclusively in patients with ADHD-for which biochemical analyses indicated that it abolish the activity of MTNR2A.	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
MTNR1A_G/A_G166E	point mutation	1 (0/0/1)
MTNR1A_C/T_A266V	point mutation	1 (0/0/1)
MTNR1A_C/G_Y170X	point mutation	1 (1/0/0)
MTNR1A_A/T_K334N	point mutation	1 (0/0/1)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042562	hormone binding	Molecular Function	IPI[10531408]	4
GO:0030828	positive regulation of cGMP biosynthetic process	Biological Process	IDA[10531408]	3
GO:0097159	organic cyclic compound binding	Molecular Function	IPI[10531408]	1
GO:0043235	receptor complex	Cellular Component	IDA[10531408]	11
GO:0005887	integral to plasma membrane	Cellular Component	IDA[10531408]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007617	mating behavior	Biological Process	TAS[7946354]	4
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[9645677]	18
GO:0008502	melatonin receptor activity	Molecular Function		2
GO:0007623	circadian rhythm	Biological Process	TAS[9645677]	15

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with MTNR1A (count: 0)

Genes shared at least 2 KEGG pathways with MTNR1A (count: 0)

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Region: chr4:187347700..187476721 View in gBrowse