ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PTPRN
Symbol Alias	IA-2
Approved Name	protein tyrosine phosphatase, receptor type, N
Location	2q35-q36.1
Position	chr2:220154345-220174370, -
External Links	HGNC: 9676 Entrez Gene: 5798 Ensembl: ENSG00000054356 UCSC: uc002vkz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8024693]	220
GO:0005515	protein binding	Molecular Function	IPI[16273344]	910
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0009749	response to glucose stimulus	Biological Process		10
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity	Molecular Function	TAS[8024693]	5
GO:0000302	response to reactive oxygen species	Biological Process	IDA[18048354]	2
GO:0051591	response to cAMP	Biological Process		11
GO:0032868	response to insulin stimulus	Biological Process		11
GO:0030507	spectrin binding	Molecular Function	IPI[11086001]	2
GO:0051020	GTPase binding	Molecular Function		3
GO:0043627	response to estrogen stimulus	Biological Process		11

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04940	Type I diabetes mellitus	6	Type I diabetes mellitus is a disease that results from auto...... Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma). More...

Genes shared at least 5 GO terms with PTPRN (count: 0)

Genes shared at least 2 KEGG pathways with PTPRN (count: 0)

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Region: chr2:220154345..220174370 View in gBrowse