ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GPR50
Symbol Alias	H9, Mel1c
Approved Name	G protein-coupled receptor 50
Location	Xq28
Position	chrX:150345056-150349937, +
External Links	HGNC: 4506 Entrez Gene: 9248 Ensembl: ENSG00000102195 UCSC: uc010ntg.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Chaste P, 2011	Several damaging mutations were found in patients with ADHD, but no significant enrichment compared with the general population.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 4)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
GPR50_Del502-505	insertion/deletion	1 (0/0/1)
GPR50_I606V	point mutation	1 (0/0/1)
GPR50_S493R	point mutation	1 (0/0/1)
GPR50_T532A	point mutation	1 (0/0/1)

Gene related regions (count: 0)

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[8647286]	72
GO:0007267	cell-cell signaling	Biological Process	TAS[8647286]	38
GO:0004930	G-protein coupled receptor activity	Molecular Function		236
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8647286]	220

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with GPR50 (count: 0)

Genes shared at least 2 KEGG pathways with GPR50 (count: 0)

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Region: chrX:150345056..150349937 View in gBrowse