Gene Report
Basic Info
Approved Symbol |
LILRB3
|
Symbol Alias |
LIR-3, HL9, ILT5, LIR3, CD85a |
Approved Name |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 |
Location |
19q13.4 |
Position |
chr19:54720147-54746602, - |
External Links |
HGNC: 6607
Entrez Gene: 11025
Ensembl: ENSG00000204577
UCSC: uc002qee.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 7)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04662 |
B cell receptor signaling pathway |
14 |
B cells are an important component of adaptive immunity. The......
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
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|
hsa04380 |
Osteoclast differentiation |
25 |
The osteoclasts, multinucleared cells originating from the h......
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
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|
Genes shared at least 5 GO terms with LILRB3 (count: 1)
Genes shared at least 2 KEGG pathways with LILRB3 (count: 8)
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