ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0045944
Name	positive regulation of transcription from RNA polymerase II promoter
Type	Biological Process
No. of Genes in ADHDgene	131
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 131)

Literature-origin genes (count: 21)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)
LMO4	LIM domain only 4	1p22.3	1(0/1/0)
ATXN1	ataxin 1	6p23	1(0/0/1)
ARRB1	arrestin, beta 1	11q13	2(1/1/0)	IMP[16325578]
NTF3	neurotrophin 3	12p13	3(1/2/0)
NR4A2	nuclear receptor subfamily 4, group A, member 2	2q22-q23	2(0/2/0)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)
HOXB1	homeobox B1	17q21.32	1(0/0/1)
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	IDA[12358785]
DRD3	dopamine receptor D3	3q13.3	8(1/7/0)
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	2p16.1	1(0/0/1)	ISS[19616629]
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)	IGI[9576906]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[18093989]; IMP[18093989]
CDH13	cadherin 13, H-cadherin (heart)	16q23.3	3(1/1/1)	IMP[16099944]
MEIS2	Meis homeobox 2	15q14	1(0/0/1)
DRD2	dopamine receptor D2	11q22-q23	10(3/7/0)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)
ISL1	ISL LIM homeobox 1	5q11.2	1(0/1/0)
ADRB2	adrenergic, beta-2-, receptor, surface	5q31-q32	2(1/1/0)
FOXP1	forkhead box P1	3p14.1	1(0/0/1)
TFEB	transcription factor EB	6p21	1(0/0/1)	IDA[19556463]

Genes from other sources (count: 110)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MED14	mediator complex subunit 14	Mapped by PBA pathway	IDA[12037571]
UBC	ubiquitin C	Mapped by CNV
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region	IDA[15247905]
BARX2	BARX homeobox 2	Mapped by significant region
UTF1	undifferentiated embryonic cell transcription factor 1	Mapped by CNV	IDA[9748258]
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region
HOXA2	homeobox A2	Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[17350185]
TP53BP1	tumor protein p53 binding protein 1	Mapped by LD-proxy; Mapped by literature SNP	IMP[17805299]
WWOX	WW domain containing oxidoreductase	Mapped by significant region
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV	IDA[18818105]
MED13	mediator complex subunit 13	Mapped by PBA pathway	IDA[12037571]
SQSTM1	sequestosome 1	Mapped by CNV	TAS[12857745]
NCK1	NCK adaptor protein 1	Mapped by PBA pathway	IDA[10026169]
MED12	mediator complex subunit 12	Mapped by PBA pathway	IDA[12037571]
PRKD1	protein kinase D1	Mapped by significant region	IMP[18059339]
GATA6	GATA binding protein 6	Mapped by significant region	IDA[19497978]
NCK2	NCK adaptor protein 2	Mapped by PBA pathway	IDA[10026169]
FOXD4	forkhead box D4	Mapped by CNV
AHI1	Abelson helper integration site 1	Mapped by significant region
HOXA5	homeobox A5	Mapped by significant region	IDA[10879542]
ESRRA	estrogen-related receptor alpha	Mapped by significant region
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway	IDA[12037571]; IMP[17641689]
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region
HNF1B	HNF1 homeobox B	Mapped by CNV
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV
HOXA7	homeobox A7	Mapped by significant region
BSX	brain-specific homeobox	Mapped by significant region
NRIP1	nuclear receptor interacting protein 1	Mapped by PBA pathway	IDA[10364267]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region
FLCN	folliculin	Mapped by significant region
NPAS4	neuronal PAS domain protein 4	Mapped by significant region
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	Mapped by significant region
AATF	apoptosis antagonizing transcription factor	Mapped by CNV	IDA[18049476]
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	Mapped by significant region
MED17	mediator complex subunit 17	Mapped by PBA pathway; Mapped by significant region	IDA[12037571]
GREM1	gremlin 1	Mapped by CNV; Mapped by significant region	ISS[9660951]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region	IDA[12242332]
E2F5	E2F transcription factor 5, p130-binding	Mapped by CNV
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	Mapped by significant region	IDA[19245366]
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Mapped by significant region
CRLF3	cytokine receptor-like factor 3	Mapped by CNV	IDA[19427400]
MTA2	metastasis associated 1 family, member 2	Mapped by significant region
RORA	RAR-related orphan receptor A	Mapped by LD-proxy; Mapped by literature SNP	IDA[17545671]
NPAS2	neuronal PAS domain protein 2	Mapped by CNV	IGI[9576906]
PHOX2A	paired-like homeobox 2a	Mapped by significant region	IDA[16280598]; IMP[19573018]
SNW1	SNW domain containing 1	Mapped by PBA pathway	IDA[14985122]
HEY2	hairy/enhancer-of-split related with YRPW motif 2	Mapped by significant region
DAB2IP	DAB2 interacting protein	Mapped by significant region	IDA[15310755]
STRN3	striatin, calmodulin binding protein 3	Mapped by significant region	IDA[11570823]
SS18	synovial sarcoma translocation, chromosome 18	Mapped by significant region	IDA[15919756]
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Mapped by LD-proxy
NR5A1	nuclear receptor subfamily 5, group A, member 1	Mapped by significant region	IMP[17664281]
EVX1	even-skipped homeobox 1	Mapped by significant region
UBB	ubiquitin B	Mapped by significant region
IKZF1	IKAROS family zinc finger 1 (Ikaros)	Mapped by LD-proxy
FOXF1	forkhead box F1	Mapped by significant region
BCL9L	B-cell CLL/lymphoma 9-like	Mapped by significant region	IMP[19328798]
MURC	muscle-related coiled-coil protein	Mapped by significant region
PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	Mapped by PBA pathway	IDA[11854298]
YAP1	Yes-associated protein 1	Mapped by significant region
PRPF6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)	Mapped by PBA pathway	IDA[16414017]
LPIN1	lipin 1	Mapped by significant region
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	Mapped by significant region
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mapped by significant region
MCF2L	MCF.2 cell line derived transforming sequence-like	Mapped by CNV
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV	IDA[7559606]
BCL9	B-cell CLL/lymphoma 9	Mapped by CNV
LHX2	LIM homeobox 2	Mapped by significant region
TBX1	T-box 1	Mapped by CNV
RBM14	RNA binding motif protein 14	Mapped by significant region	IDA[15919756]
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[17324931]
HOXA1	homeobox A1	Mapped by significant region
ARID3C	AT rich interactive domain 3C (BRIGHT-like)	Mapped by LD-proxy
MAML2	mastermind-like 2 (Drosophila)	Mapped by significant region	IDA[12370315]
IRF7	interferon regulatory factor 7	Mapped by LD-proxy	IDA[16127453]
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Mapped by CNV	IDA[11950834]
MAML1	mastermind-like 1 (Drosophila)	Mapped by CNV	IDA[16510869]
LRP5	low density lipoprotein receptor-related protein 5	Mapped by CNV; Mapped by significant region	IDA[12857724]
PYGO1	pygopus homolog 1 (Drosophila)	Mapped by LD-proxy; Mapped by literature SNP
THRAP3	thyroid hormone receptor associated protein 3	Mapped by PBA pathway	IDA[12037571]
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	Mapped by significant region	ISS[18292087]
FGF4	fibroblast growth factor 4	Mapped by significant region
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	Mapped by CNV	IMP[18663143]
TCF21	transcription factor 21	Mapped by CNV; Mapped by significant region
MEN1	multiple endocrine neoplasia I	Mapped by significant region
NCOA6	nuclear receptor coactivator 6	Mapped by PBA pathway	IDA[11443112]
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	Mapped by significant region
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	Mapped by significant region
NCOA7	nuclear receptor coactivator 7	Mapped by significant region	IDA[11971969]
FOXG1	forkhead box G1	Mapped by significant region
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	Mapped by significant region
CDON	Cdon homolog (mouse)	Mapped by significant region
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway	ISS[15528384]
HSF2	heat shock transcription factor 2	Mapped by significant region	IDA[10561509]
UBE3A	ubiquitin protein ligase E3A	Mapped by CNV; Mapped by significant region
VGLL2	vestigial like 2 (Drosophila)	Mapped by significant region
TLR4	toll-like receptor 4	Mapped by significant region
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy
FADD	Fas (TNFRSF6)-associated via death domain	Mapped by significant region	IDA[16127453]
ZNF462	zinc finger protein 462	Mapped by significant region
KLF13	Kruppel-like factor 13	Mapped by CNV; Mapped by significant region
IHH	Indian hedgehog	Mapped by significant region
HOXA13	homeobox A13	Mapped by significant region
CD3D	CD3d molecule, delta (CD3-TCR complex)	Mapped by significant region	IDA[2017177]
ONECUT2	one cut homeobox 2	Mapped by significant region
MAPK7	mitogen-activated protein kinase 7	Mapped by significant region
POU2F3	POU class 2 homeobox 3	Mapped by significant region