ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0007165
Name	signal transduction
Type	Biological Process
No. of Genes in ADHDgene	171
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 171)

Literature-origin genes (count: 26)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
NTF3	neurotrophin 3	12p13	3(1/2/0)	TAS[2236018]
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	1(1/0/0)	TAS[8243272]
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	TAS[2823383]
TSPAN8	tetraspanin 8	12q14.1-q21.1	1(0/1/0)	TAS[2395876]
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	TAS[7839144]
ADRBK1	adrenergic, beta, receptor kinase 1	11q13	1(0/1/0)
CNTFR	ciliary neurotrophic factor receptor	9p13	1(1/0/0)	NAS[1648265]
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	TAS[7830769]
ADRBK2	adrenergic, beta, receptor kinase 2	22q11	1(0/1/0)
CNTF	ciliary neurotrophic factor	11q12	1(1/0/0)	NAS[1840538]
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)	TAS[10198158]
CHRNA3	cholinergic receptor, nicotinic, alpha 3	15q24	1(0/1/0)	IDA[8906617]
UNC5B	unc-5 homolog B (C. elegans)	10q22.2	1(0/0/1)
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	17	1(0/1/0)	TAS[10604473]
CSNK1E	casein kinase 1, epsilon	22q13.1	2(1/1/0)	TAS[7797465]
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	3p24.3	1(0/0/1)	TAS[9571151]
CHRNA4	cholinergic receptor, nicotinic, alpha 4	20	7(4/3/0)	IDA[8906617]
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	12q23	2(2/0/0)	TAS[7958835]
ANK3	ankyrin 3, node of Ranvier (ankyrin G)	10q21	1(0/1/0)
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	4p16.1	1(1/0/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7	15q13.3	2(0/1/1)	IDA[8906617]
NET1	neuroepithelial cell transforming 1	10p15	0	TAS[8649828]
NR4A2	nuclear receptor subfamily 4, group A, member 2	2q22-q23	2(0/2/0)	NAS[7877627]
NR3C2	nuclear receptor subfamily 3, group C, member 2	4q31	1(0/1/0)	TAS[3037703]
PRKG1	protein kinase, cGMP-dependent, type I	10q11.2	1(0/0/1)
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)	TAS[8396931]

Genes from other sources (count: 145)

Approved Symbol	Approved Name	Source	Evidence[PMID]
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Mapped by CNV	NAS[8894693]
PGR	progesterone receptor	Mapped by significant region	TAS[1557371]
WWP1	WW domain containing E3 ubiquitin protein ligase 1	Mapped by CNV	NAS[9169421]
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV
SMC3	structural maintenance of chromosomes 3	Mapped by PBA pathway	IDA[12651860]
GPR123	G protein-coupled receptor 123	Mapped by CNV	NAS[17212699]
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IDA[16849327]
PDE4D	phosphodiesterase 4D, cAMP-specific	Mapped by CNV
P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	Mapped by CNV	TAS[9242461]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[14633705]
NCK2	NCK adaptor protein 2	Mapped by PBA pathway	TAS[9737977]
ZNF259	zinc finger protein 259	Mapped by significant region	TAS[8650580]
GJA1	gap junction protein, alpha 1, 43kDa	Mapped by significant region	IMP[12761501]
RASA1	RAS p21 protein activator (GTPase activating protein) 1	Mapped by PBA pathway	IDA[1756860]
OR6A2	olfactory receptor, family 6, subfamily A, member 2	Mapped by CNV	NAS[9787077]
ATM	ataxia telangiectasia mutated	Mapped by CNV; Mapped by significant region	TAS[7792600]
TNC	tenascin C	Mapped by significant region
STAP1	signal transducing adaptor family member 1	Mapped by significant region	TAS[10518561]
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	Mapped by CNV	NAS[8103515]
CNGB3	cyclic nucleotide gated channel beta 3	Mapped by CNV	NAS[10888875]
CABP2	calcium binding protein 2	Mapped by significant region	TAS[10625670]
CABP4	calcium binding protein 4	Mapped by significant region	NAS[10625670]
RANBP1	RAN binding protein 1	Mapped by CNV	TAS[16130169]
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	Mapped by CNV; Mapped by significant region	TAS[1321750]
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	Mapped by significant region	TAS[9221902]
IGFBP5	insulin-like growth factor binding protein 5	Mapped by significant region	NAS[7525452]
FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	Mapped by CNV	TAS[2142460]
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region
TXN	thioredoxin	Mapped by significant region	TAS[10947064]
CXCR2	chemokine (C-X-C motif) receptor 2	Mapped by significant region	IDA[10820279]
PRKD1	protein kinase D1	Mapped by significant region	TAS[8119958]
PDE7B	phosphodiesterase 7B	Mapped by significant region
HBS1L	HBS1-like (S. cerevisiae)	Mapped by significant region	TAS[9872408]
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	Mapped by CNV; Mapped by significant region	TAS[1664410]
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway	TAS[10491003]
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	Mapped by significant region
DRG2	developmentally regulated GTP binding protein 2	Mapped by significant region	TAS[7929244]
KCNIP1	Kv channel interacting protein 1	Mapped by LD-proxy; Mapped by literature SNP	TAS[10676964]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV
RIT2	Ras-like without CAAX 2	Mapped by significant region	TAS[8918462]
SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	Mapped by significant region	NAS[10587371]
IL7R	interleukin 7 receptor	Mapped by significant region	TAS[2317865]
NRGN	neurogranin (protein kinase C substrate, RC3)	Mapped by significant region	TAS[10075657]
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	Mapped by CNV	TAS[9367155]
PDIA3	protein disulfide isomerase family A, member 3	Mapped by PBA pathway	TAS[3398923]
CLCN6	chloride channel 6	Mapped by LD-proxy	NAS[9224655]
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	Mapped by CNV	NAS[8648241]
ARHGAP42	Rho GTPase activating protein 42	Mapped by significant region
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Mapped by significant region	TAS[9804755]
OR5I1	olfactory receptor, family 5, subfamily I, member 1	Mapped by CNV; Mapped by significant region	NAS[9787077]
ADCY4	adenylate cyclase 4	Mapped by significant region
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	Mapped by significant region	TAS[10074428]
IQGAP2	IQ motif containing GTPase activating protein 2	Mapped by CNV	TAS[8756646]
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region	TAS[10673050]
OMP	olfactory marker protein	Mapped by significant region	TAS[8790421]
PRKCB	protein kinase C, beta	Mapped by significant region	NAS[3755548]
TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	Mapped by significant region	NAS[9872942]
TAAR5	trace amine associated receptor 5	Mapped by significant region	TAS[9464258]
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy	IDA[10572067]
CHL1	cell adhesion molecule with homology to L1CAM (close homolog of L1)	Mapped by CNV	TAS[9799093]
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	Mapped by significant region	TAS[9789079]
COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)	Mapped by significant region	TAS[9535219]
RORA	RAR-related orphan receptor A	Mapped by LD-proxy; Mapped by literature SNP	NAS[7926749]
CHKA	choline kinase alpha	Mapped by significant region	TAS[10363580]
PI4KA	phosphatidylinositol 4-kinase, catalytic, alpha	Mapped by CNV	NAS[7961848]
GRP	gastrin-releasing peptide	Mapped by significant region	NAS[3027901]
ITK	IL2-inducible T-cell kinase	Mapped by significant region	TAS[8364206]
ANGPTL2	angiopoietin-like 2	Mapped by significant region
TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	Mapped by significant region	TAS[7913952]
PRKAB2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	Mapped by CNV	TAS[9575201]
EDARADD	EDAR-associated death domain	Mapped by CNV
PPP1R12B	protein phosphatase 1, regulatory (inhibitor) subunit 12B	Mapped by LD-proxy; Mapped by literature SNP	TAS[9570949]
IL10RA	interleukin 10 receptor, alpha	Mapped by significant region	TAS[8407942]
ANGPTL5	angiopoietin-like 5	Mapped by significant region
NMU	neuromedin U	Mapped by LD-proxy	TAS[7619205]
MAPRE2	microtubule-associated protein, RP/EB family, member 2	Mapped by significant region	TAS[9233623]
PYCARD	PYD and CARD domain containing	Mapped by CNV	NAS[12019269]
CHRNB4	cholinergic receptor, nicotinic, beta 4	Mapped by LD-proxy	IDA[8906617]
CACNA1I	calcium channel, voltage-dependent, T type, alpha 1I subunit	Mapped by CNV	TAS[10454147]
TRAF1	TNF receptor-associated factor 1	Mapped by significant region
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	Mapped by LD-proxy; Mapped by literature SNP
APOL3	apolipoprotein L, 3	Mapped by CNV	IMP[12761501]
CNTNAP2	contactin associated protein-like 2	Mapped by CNV
SERGEF	secretion regulating guanine nucleotide exchange factor	Mapped by LD-proxy	TAS[10571079]
GNG10	guanine nucleotide binding protein (G protein), gamma 10	Mapped by significant region	TAS[7665596]
STMN1	stathmin 1	Mapped by PBA pathway	NAS[8003023]
RIPK3	receptor-interacting serine-threonine kinase 3	Mapped by significant region	TAS[10339433]
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy	TAS[1540184]
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP
INHA	inhibin, alpha	Mapped by significant region	TAS[3267209]
PPP1R1C	protein phosphatase 1, regulatory (inhibitor) subunit 1C	Mapped by LD-proxy; Mapped by literature SNP
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	Mapped by significant region	TAS[8391931]
CHRNA5	cholinergic receptor, nicotinic, alpha 5	Mapped by LD-proxy	NAS[9009220]
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	Mapped by significant region	TAS[1683630]
RIN1	Ras and Rab interactor 1	Mapped by significant region
ROR2	receptor tyrosine kinase-like orphan receptor 2	Mapped by significant region	TAS[1334494]
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	Mapped by significant region	TAS[7796809]
EDNRA	endothelin receptor type A	Mapped by PBA pathway	TAS[1326535]
IFNGR1	interferon gamma receptor 1	Mapped by significant region	TAS[2971451]
IL11RA	interleukin 11 receptor, alpha	Mapped by LD-proxy	TAS[8786120]
FYB	FYN binding protein	Mapped by significant region	TAS[9207119]
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	Mapped by CNV; Mapped by PBA pathway	TAS[7670466]
SPN	sialophorin	Mapped by CNV	TAS[2023632]
PPP2R2D	protein phosphatase 2, regulatory subunit B, delta	Mapped by CNV
CNTNAP4	contactin associated protein-like 4	Mapped by significant region
FGF9	fibroblast growth factor 9 (glia-activating factor)	Mapped by significant region	TAS[8575785]
OPTN	optineurin	Mapped by PBA pathway	TAS[9488477]
TNN	tenascin N	Mapped by significant region
SIPA1	signal-induced proliferation-associated 1	Mapped by significant region	TAS[9346962]
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Mapped by significant region	TAS[1373520]
DTNA	dystrobrevin, alpha	Mapped by significant region	TAS[10767327]
FGF4	fibroblast growth factor 4	Mapped by significant region	TAS[2959959]
ULK2	unc-51-like kinase 2 (C. elegans)	Mapped by significant region
PDCL	phosducin-like	Mapped by significant region	NAS[10524200]
FAM126A	family with sequence similarity 126, member A	Mapped by significant region	NAS[10910037]
TRPM1	transient receptor potential cation channel, subfamily M, member 1	Mapped by CNV; Mapped by PBA pathway; Mapped by significant region
TRHDE	thyrotropin-releasing hormone degrading enzyme	Mapped by LD-proxy	TAS[10491199]
AIP	aryl hydrocarbon receptor interacting protein	Mapped by significant region	TAS[9111057]
CHRM1	cholinergic receptor, muscarinic 1	Mapped by PBA pathway; Mapped by significant region	TAS[9614217]
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region	IMP[12761501]
TRIM13	tripartite motif containing 13	Mapped by LD-proxy	IMP[12761501]
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	Mapped by CNV
SKAP2	src kinase associated phosphoprotein 2	Mapped by significant region	TAS[9837776]
GAPVD1	GTPase activating protein and VPS9 domains 1	Mapped by significant region
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway	TAS[7603572]
AKAP10	A kinase (PRKA) anchor protein 10	Mapped by significant region	TAS[9326583]
MAPK7	mitogen-activated protein kinase 7	Mapped by significant region	TAS[7646528]
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway	TAS[9886417]
CAPN5	calpain 5	Mapped by significant region	TAS[9339374]
COL15A1	collagen, type XV, alpha 1	Mapped by significant region	NAS[10891348]
LPXN	leupaxin	Mapped by significant region	TAS[9565592]
CDKL2	cyclin-dependent kinase-like 2 (CDC2-related kinase)	Mapped by CNV	TAS[9000130]
TNR	tenascin R (restrictin, janusin)	Mapped by significant region
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	Mapped by CNV	TAS[9223106]
IL5RA	interleukin 5 receptor, alpha	Mapped by CNV	TAS[1732409]
FGF3	fibroblast growth factor 3	Mapped by significant region	TAS[2470007]
MFAP4	microfibrillar-associated protein 4	Mapped by significant region
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	Mapped by significant region	TAS[9751059]
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region	TAS[8557660]
CHRM3	cholinergic receptor, muscarinic 3	Mapped by CNV; Mapped by PBA pathway	TAS[10940357]
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	Mapped by LD-proxy; Mapped by literature SNP	IMP[12761501]
SPA17	sperm autoantigenic protein 17	Mapped by significant region
PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	Mapped by significant region	TAS[9447982]
ATF6	activating transcription factor 6	Mapped by CNV	TAS[9271374]
CLTCL1	clathrin, heavy chain-like 1	Mapped by CNV	TAS[8844170]