ADHDgene Database

Gene Report

Basic Info

Approved Symbol	OPTN
Previous Symbol	GLC1E
Symbol Alias	FIP2, HYPL, TFIIIA-INTP, NRP, HIP7
Approved Name	optineurin
Previous Name	glaucoma 1, open angle, E (adult-onset)
Location	10p14
Position	chr10:13141449-13180291, +
External Links	HGNC: 17142 Entrez Gene: 10133 Ensembl: ENSG00000123240 UCSC: uc001ilx.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048193	Golgi vesicle transport	Biological Process		49

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008022	protein C-terminus binding	Molecular Function	IPI[15837803]	32
GO:0008219	cell death	Biological Process		33
GO:0043001	Golgi to plasma membrane protein transport	Biological Process	IMP[15837803]	3
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0090161	Golgi ribbon formation	Biological Process	IDA[15837803]	1
GO:0000042	protein targeting to Golgi	Biological Process	IMP[15837803]	4
GO:0005515	protein binding	Molecular Function		910
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component	IDA[15837803]	157
GO:0005802	trans-Golgi network	Cellular Component		28
GO:0007030	Golgi organization	Biological Process	IMP[15837803]	11
GO:0007165	signal transduction	Biological Process	TAS[9488477]	171

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with OPTN (count: 3)

Gene Symbol	Pathway Count	Pathway List
ATXN2	7	protein C-terminus binding; cell death; perinuclear region of cytoplasm; protein binding; cytoplasm; Golgi apparatus; trans-Golgi network;
PRKD1	7	Golgi vesicle transport; protein binding; cytoplasm; Golgi apparatus; trans-Golgi network; Golgi organization; signal transduction;
PARK2	5	cell death; perinuclear region of cytoplasm; protein binding; cytoplasm; Golgi apparatus;

Genes shared at least 2 KEGG pathways with OPTN (count: 0)

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Region: chr10:13141449..13180291 View in gBrowse