ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04080
Name Neuroactive ligand-receptor interaction
No. of Genes in ADHDgene  89
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 89)

Literature-origin genes (count: 41)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
GRM8 glutamate receptor, metabotropic 8 7q31.3-q32.1 1(1/0/0)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 1(0/1/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 1(1/0/0)
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 2(1/1/0)
GRM7 glutamate receptor, metabotropic 7 3p26-p25 3(2/1/0)
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 1(1/0/0)
OXTR oxytocin receptor 3p25 1(0/1/0)
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5q11.2-q13 2(2/0/0)
ADRA2C adrenoceptor alpha 2C 4p16.3 7(2/4/1)
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0)
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 4p12 1(0/0/1)
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0)
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0)
MTNR1A melatonin receptor 1A 4q35 1(1/0/0)
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1)
MC4R melanocortin 4 receptor 18q22 1(0/1/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 1(0/1/0)
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0)
GRIK4 glutamate receptor, ionotropic, kainate 4 11q23.3 1(0/1/0)
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 2(0/2/0)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled 1p36.3-p34.3 2(1/1/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0)
DRD5 dopamine receptor D5 4p16.1 22(14/6/2)
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0)
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6q14-q15 2(2/0/0)
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0)
ADRA2A adrenoceptor alpha 2A 10q25.2 13(4/9/0)
ADRA2B adrenoceptor alpha 2B 2q11.1 1(1/0/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0)
GPR50 G protein-coupled receptor 50 Xq28 1(0/0/1)
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1)
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1)
GRID2 glutamate receptor, ionotropic, delta 2 4q22 1(0/0/1)
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0)
DRD3 dopamine receptor D3 3q13.3 8(1/7/0)
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0)
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3p12 1(0/1/0)
OPRM1 opioid receptor, mu 1 6q24-q25 1(1/0/0)
DRD4 dopamine receptor D4 11p15.5 67(49/18/0)

Genes from other sources Help(count: 48)

Approved Symbol Approved Name Location Source
PTGER4 prostaglandin E receptor 4 (subtype EP4) 5p13.1 Mapped by significant region
GNRHR gonadotropin-releasing hormone receptor 4q21.2 Mapped by significant region
F2RL2 coagulation factor II (thrombin) receptor-like 2 5q13 Mapped by PBA pathway
ADORA2A adenosine A2a receptor 22q11.23 Mapped by CNV
LPAR1 lysophosphatidic acid receptor 1 9q Mapped by significant region
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 15q12 Mapped by CNV; Mapped by significant region
MC5R melanocortin 5 receptor 18p11.2 Mapped by CNV
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 15q12 Mapped by CNV; Mapped by significant region
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 9q22.1-q22.3 Mapped by significant region
GHR growth hormone receptor 5p14-p12 Mapped by CNV; Mapped by significant region
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 11q13.5-q14.1 Mapped by significant region
LTB4R leukotriene B4 receptor 14q11.2-q12 Mapped by significant region
TAAR9 trace amine associated receptor 9 (gene/pseudogene) 6q23.2 Mapped by significant region
GPR83 G protein-coupled receptor 83 11q21 Mapped by significant region
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 15q12 Mapped by CNV; Mapped by significant region
GRM6 glutamate receptor, metabotropic 6 5q35 Mapped by CNV
S1PR3 sphingosine-1-phosphate receptor 3 9q22.1-q22.2 Mapped by significant region
TAAR5 trace amine associated receptor 5 6q23.2 Mapped by significant region
APLNR apelin receptor 11q12.1 Mapped by significant region
SCTR secretin receptor 2q14.1 Mapped by LD-proxy
TAAR8 trace amine associated receptor 8 6q23.2 Mapped by significant region
TACR3 tachykinin receptor 3 4q25 Mapped by CNV
TAAR1 trace amine associated receptor 1 6q23.1 Mapped by significant region
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 Mapped by significant region; Mapped by PBA pathway
CHRM3 cholinergic receptor, muscarinic 3 1q43 Mapped by CNV; Mapped by PBA pathway
TAAR2 trace amine associated receptor 2 6q24 Mapped by significant region
GRIA4 glutamate receptor, ionotropic, AMPA 4 11q22 Mapped by significant region
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 18p11.2 Mapped by CNV
SSTR5 somatostatin receptor 5 16p13.3 Mapped by significant region
TRPV1 transient receptor potential cation channel, subfamily V, member 1 17p13.3 Mapped by PBA pathway
HRH4 histamine receptor H4 18q11.2 Mapped by significant region
PRLR prolactin receptor 5p14-p13 Mapped by significant region
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 16q24.3 Mapped by significant region
LTB4R2 leukotriene B4 receptor 2 14q11.2-q12 Mapped by significant region
CHRM5 cholinergic receptor, muscarinic 5 15q26 Mapped by CNV; Mapped by PBA pathway
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 11q12 Mapped by significant region
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 22q11.21 Mapped by CNV
TAAR6 trace amine associated receptor 6 6q23.1 Mapped by significant region
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 11q13.5 Mapped by significant region
CTSG cathepsin G 14q12 Mapped by significant region
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 9q31.1 Mapped by significant region
CCKAR cholecystokinin A receptor 4p15.2 Mapped by CNV
CCKBR cholecystokinin B receptor 11p15.4 Mapped by CNV; Mapped by PBA pathway
C3AR1 complement component 3a receptor 1 12p13.31 Mapped by PBA pathway
GIPR gastric inhibitory polypeptide receptor 19q13.2-q13.3 Mapped by LD-proxy
EDNRA endothelin receptor type A 4q31.22 Mapped by PBA pathway
BDKRB2 bradykinin receptor B2 14q32.1-q32.2 Mapped by PBA pathway
NTSR2 neurotensin receptor 2 2p25.1 Mapped by significant region