ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GABRG1
Approved Name	gamma-aminobutyric acid (GABA) A receptor, gamma 1
Location	4p12
Position	chr4:46037786-46126098, -
External Links	HGNC: 4086 Entrez Gene: 2565 Ensembl: ENSG00000163285 UCSC: uc003gxb.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lionel, A. C., 2011	De novo and/or rare inherited CNVs associated with this gene were detected for not only ADHD, but also other neurodevelopmental conditions including ASD.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lionel[2011]_20	chr4:0-0 (NCBI36 / hg18)	64	4p12	Loss	M

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005886	plasma membrane	Cellular Component	772
GO:0007214	gamma-aminobutyric acid signaling pathway	Biological Process	5
GO:0007268	synaptic transmission	Biological Process	96
GO:0030054	cell junction	Cellular Component	77
GO:0004890	GABA-A receptor activity	Molecular Function	4
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function	7
GO:0005254	chloride channel activity	Molecular Function	6
GO:0034707	chloride channel complex	Cellular Component	7
GO:0043235	receptor complex	Cellular Component	11
GO:0045211	postsynaptic membrane	Cellular Component	41
GO:0050811	GABA receptor binding	Molecular Function	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with GABRG1 (count: 5)

Gene Symbol	Pathway Count	Pathway List
GABRA5	11	plasma membrane; gamma-aminobutyric acid signaling pathway; synaptic transmission; cell junction; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; chloride channel complex; receptor complex; postsynaptic membrane; GABA receptor binding;
GABRG3	9	plasma membrane; gamma-aminobutyric acid signaling pathway; synaptic transmission; cell junction; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; chloride channel complex; postsynaptic membrane;
GABRB3	8	plasma membrane; synaptic transmission; cell junction; GABA-A receptor activity; extracellular ligand-gated ion channel activity; chloride channel activity; chloride channel complex; postsynaptic membrane;
GABBR2	5	plasma membrane; gamma-aminobutyric acid signaling pathway; synaptic transmission; cell junction; postsynaptic membrane;
HTR3A	5	plasma membrane; synaptic transmission; cell junction; extracellular ligand-gated ion channel activity; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with GABRG1 (count: 0)

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Region: chr4:46037786..46126098 View in gBrowse