ADHDgene Database
  • Hot Results
  • Quick Search
Keyword:
Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0046872
Name metal ion binding
Type Molecular Function
No. of Genes in ADHDgene  170
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 170)

Literature-origin genes (count: 20)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DMRT2 doublesex and mab-3 related transcription factor 2 9p24.3 1(0/0/1)
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 17p13 1(0/0/1)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0)
ITGA1 integrin, alpha 1 5q11.1 1(0/1/0)
ITGA11 integrin, alpha 11 15q22.3-q23 1(0/0/1)
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 16q24.1 2(0/1/1)
STS steroid sulfatase (microsomal), isozyme S Xp22.32 3(2/1/0)
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 Xq28 1(0/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1)
NLN neurolysin (metallopeptidase M3 family) 5q12.3 1(1/0/0)
NRXN1 neurexin 1 2p16.3 1(0/1/0)
BMPR1B bone morphogenetic protein receptor, type IB 4q23-q24 1(0/0/1)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 22q11.1-q11.2 1(0/1/0)
CLYBL citrate lyase beta like 13q32.3 1(0/0/1)
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 1p13 1(1/0/0)
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F 22q11.22 1(0/0/1)
DGKH diacylglycerol kinase, eta 13q13.3 1(1/0/0)
NT5DC3 5'-nucleotidase domain containing 3 12q22-q23.1 1(0/0/1)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0)

Genes from other sources Help (count: 150)

Approved Symbol Approved Name Source Evidence[PMID]
CNOT6 CCR4-NOT transcription complex, subunit 6 Mapped by CNV
RUFY4 RUN and FYVE domain containing 4 Mapped by significant region
KDM4D lysine (K)-specific demethylase 4D Mapped by significant region
MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase Mapped by CNV
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa Mapped by significant region
COLEC12 collectin sub-family member 12 Mapped by CNV
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region
NT5M 5',3'-nucleotidase, mitochondrial Mapped by significant region
LMAN2L lectin, mannose-binding 2-like Mapped by PBA pathway
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Mapped by LD-proxy
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B Mapped by CNV
GMPR2 guanosine monophosphate reductase 2 Mapped by significant region
CYB5B cytochrome b5 type B (outer mitochondrial membrane) Mapped by CNV
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway
STAC3 SH3 and cysteine rich domain 3 Mapped by CNV
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway
KARS lysyl-tRNA synthetase Mapped by significant region
COL27A1 collagen, type XXVII, alpha 1 Mapped by significant region
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region
DAK dihydroxyacetone kinase 2 homolog (S. cerevisiae) Mapped by significant region
ALKBH5 alkB, alkylation repair homolog 5 (E. coli) Mapped by significant region
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 Mapped by significant region
PRKD1 protein kinase D1 Mapped by significant region
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 Mapped by significant region
SMG1 smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) Mapped by significant region
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa Mapped by significant region
CHPF chondroitin polymerizing factor Mapped by significant region
KAT5 K(lysine) acetyltransferase 5 Mapped by significant region
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Mapped by significant region
TIMP3 TIMP metallopeptidase inhibitor 3 Mapped by LD-proxy; Mapped by literature SNP
PDE4D phosphodiesterase 4D, cAMP-specific Mapped by CNV
DROSHA drosha, ribonuclease type III Mapped by significant region
ESCO1 establishment of cohesion 1 homolog 1 (S. cerevisiae) Mapped by significant region
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region
CHN2 chimerin (chimaerin) 2 Mapped by CNV
DAGLA diacylglycerol lipase, alpha Mapped by significant region
LMAN1 lectin, mannose-binding, 1 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by significant region
PDE7B phosphodiesterase 7B Mapped by significant region
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Mapped by CNV
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 Mapped by significant region
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator Mapped by CNV
ITK IL2-inducible T-cell kinase Mapped by significant region
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 Mapped by significant region
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway
ADAT1 adenosine deaminase, tRNA-specific 1 Mapped by significant region
HDDC2 HD domain containing 2 Mapped by significant region
HDDC3 HD domain containing 3 Mapped by LD-proxy
PPP6C protein phosphatase 6, catalytic subunit Mapped by significant region
SUMF1 sulfatase modifying factor 1 Mapped by CNV
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region
TGM7 transglutaminase 7 Mapped by LD-proxy
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region
PPP4C protein phosphatase 4, catalytic subunit Mapped by CNV
EYA4 eyes absent homolog 4 (Drosophila) Mapped by significant region
MTL5 metallothionein-like 5, testis-specific (tesmin) Mapped by CNV; Mapped by significant region NAS[10191092]
TGM1 transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) Mapped by significant region
ATP13A4 ATPase type 13A4 Mapped by CNV
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 Mapped by CNV
IREB2 iron-responsive element binding protein 2 Mapped by LD-proxy
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) Mapped by CNV
EBF1 early B-cell factor 1 Mapped by significant region
FBP2 fructose-1,6-bisphosphatase 2 Mapped by significant region
ARSJ arylsulfatase family, member J Mapped by CNV
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial Mapped by significant region
FBP1 fructose-1,6-bisphosphatase 1 Mapped by significant region IMP[8387495]
XPA xeroderma pigmentosum, complementation group A Mapped by significant region
GDE1 glycerophosphodiester phosphodiesterase 1 Mapped by significant region
NUBPL nucleotide binding protein-like Mapped by significant region
B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mapped by CNV; Mapped by significant region
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme Mapped by significant region
PC pyruvate carboxylase Mapped by significant region
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region
UPB1 ureidopropionase, beta Mapped by CNV
ACSM2A acyl-CoA synthetase medium-chain family member 2A Mapped by significant region
THAP6 THAP domain containing 6 Mapped by CNV
MDP1 magnesium-dependent phosphatase 1 Mapped by significant region
THAP7 THAP domain containing 7 Mapped by CNV
PELO pelota homolog (Drosophila) Mapped by LD-proxy; Mapped by literature SNP
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Mapped by significant region
ASXL3 additional sex combs like 3 (Drosophila) Mapped by significant region
HPX hemopexin Mapped by CNV
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region
PNLIP pancreatic lipase Mapped by PBA pathway
ACSM1 acyl-CoA synthetase medium-chain family member 1 Mapped by significant region
SYT10 synaptotagmin X Mapped by CNV
HERC2P3 hect domain and RLD 2 pseudogene 3 Mapped by significant region
PDZD8 PDZ domain containing 8 Mapped by LD-proxy
GALNS galactosamine (N-acetyl)-6-sulfate sulfatase Mapped by significant region
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) Mapped by CNV
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Mapped by significant region
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by PBA pathway
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 Mapped by significant region
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Mapped by PBA pathway
SYT9 synaptotagmin IX Mapped by CNV
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by PBA pathway; Mapped by significant region
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1 Mapped by LD-proxy; Mapped by literature SNP
ADCY4 adenylate cyclase 4 Mapped by significant region
FOLH1B folate hydrolase 1B Mapped by significant region
THOP1 thimet oligopeptidase 1 Mapped by LD-proxy
BCO2 beta-carotene oxygenase 2 Mapped by significant region
HECTD1 HECT domain containing 1 Mapped by significant region
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa Mapped by CNV
TPP1 tripeptidyl peptidase I Mapped by CNV
ACSM5 acyl-CoA synthetase medium-chain family member 5 Mapped by significant region
STK32C serine/threonine kinase 32C Mapped by CNV
BCMO1 beta-carotene 15,15'-monooxygenase 1 Mapped by significant region
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
NRXN2 neurexin 2 Mapped by significant region
ACSM3 acyl-CoA synthetase medium-chain family member 3 Mapped by significant region
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 Mapped by CNV
STK32B serine/threonine kinase 32B Mapped by CNV
ADAL adenosine deaminase-like Mapped by LD-proxy
ENDOD1 endonuclease domain containing 1 Mapped by significant region
CYBASC3 cytochrome b, ascorbate dependent 3 Mapped by significant region
CARNS1 carnosine synthase 1 Mapped by significant region
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Mapped by significant region
JMJD1C jumonji domain containing 1C Mapped by PBA pathway
PRLR prolactin receptor Mapped by significant region
DGCR8 DiGeorge syndrome critical region gene 8 Mapped by CNV
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 Mapped by significant region
ACY3 aspartoacylase (aminocyclase) 3 Mapped by significant region
USP2 ubiquitin specific peptidase 2 Mapped by significant region
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) Mapped by significant region
RPL37AP8 ribosomal protein L37a pseudogene 8 Mapped by significant region
PON2 paraoxonase 2 Mapped by PBA pathway
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 Mapped by CNV
CRYAB crystallin, alpha B Mapped by significant region
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) Mapped by significant region
RPL37A ribosomal protein L37a Mapped by significant region
STEAP2 six transmembrane epithelial antigen of the prostate 2 Mapped by PBA pathway
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K Mapped by CNV
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mapped by significant region
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Mapped by significant region
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) Mapped by PBA pathway; Mapped by significant region
MUS81 MUS81 endonuclease homolog (S. cerevisiae) Mapped by significant region
RPL37 ribosomal protein L37 Mapped by significant region
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 Mapped by PBA pathway
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 Mapped by LD-proxy
NT5DC1 5'-nucleotidase domain containing 1 Mapped by significant region
PRKRIR protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) Mapped by significant region
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway
ACACA acetyl-CoA carboxylase alpha Mapped by CNV
ZNHIT3 zinc finger, HIT-type containing 3 Mapped by CNV; Mapped by PBA pathway
COL10A1 collagen, type X, alpha 1 Mapped by significant region
ZNHIT2 zinc finger, HIT-type containing 2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014