ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHPF
Symbol Alias	CSS2, CHSY2
Approved Name	chondroitin polymerizing factor
Name Alias	chondroitin sulfate synthase 2
Location	2q35
Position	chr2:220403669-220408509, -
External Links	HGNC: 24291 Entrez Gene: 79586 Ensembl: ENSG00000123989 UCSC: uc002vmc.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	Molecular Function	1
GO:0005975	carbohydrate metabolic process	Biological Process	50
GO:0000139	Golgi membrane	Cellular Component	95
GO:0016021	integral to membrane	Cellular Component	845
GO:0030203	glycosaminoglycan metabolic process	Biological Process	20
GO:0030204	chondroitin sulfate metabolic process	Biological Process	7
GO:0030206	chondroitin sulfate biosynthetic process	Biological Process	4
GO:0032580	Golgi cisterna membrane	Cellular Component	18
GO:0044281	small molecule metabolic process	Biological Process	248
GO:0046872	metal ion binding	Molecular Function	170
GO:0047238	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	Molecular Function	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate	5	Glycosaminoglycans (GAGs) are linear polysaccharide chains c...... Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues [MD:M00057]. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b1-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities [MD:M00058]. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with CHPF (count: 11)

Gene Symbol	Pathway Count	Pathway List
B3GAT1	7	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; small molecule metabolic process; metal ion binding;
B4GALT4	7	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; Golgi cisterna membrane; small molecule metabolic process; metal ion binding;
B4GALT6	7	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; Golgi cisterna membrane; small molecule metabolic process; metal ion binding;
CHST9	7	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; small molecule metabolic process;
DSE	7	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; small molecule metabolic process;
B3GAT3	6	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; chondroitin sulfate metabolic process; small molecule metabolic process;
CHST5	5	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; small molecule metabolic process;
CHST6	5	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; small molecule metabolic process;
HS3ST2	5	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; small molecule metabolic process;
HS3ST5	5	carbohydrate metabolic process; Golgi membrane; integral to membrane; glycosaminoglycan metabolic process; small molecule metabolic process;
ST3GAL4	5	carbohydrate metabolic process; Golgi membrane; glycosaminoglycan metabolic process; Golgi cisterna membrane; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with CHPF (count: 3)

Gene Symbol	Pathway Count	Pathway List
B3GAT1	2	Glycosaminoglycan biosynthesis - chondroitin sulfate; Metabolic pathways;
B3GAT3	2	Glycosaminoglycan biosynthesis - chondroitin sulfate; Metabolic pathways;
XYLT1	2	Glycosaminoglycan biosynthesis - chondroitin sulfate; Metabolic pathways;

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Region: chr2:220403669..220408509 View in gBrowse