Gene Report
Basic Info
Approved Symbol |
CHPF
|
Symbol Alias |
CSS2, CHSY2 |
Approved Name |
chondroitin polymerizing factor |
Name Alias |
chondroitin sulfate synthase 2 |
Location |
2q35 |
Position |
chr2:220403669-220408509, - |
External Links |
HGNC: 24291
Entrez Gene: 79586
Ensembl: ENSG00000123989
UCSC: uc002vmc.3
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 11)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa00532 |
Glycosaminoglycan biosynthesis - chondroitin sulfate |
5 |
Glycosaminoglycans (GAGs) are linear polysaccharide chains c......
Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues [MD:M00057]. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b1-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities [MD:M00058]. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin.
More...
|
hsa01100 |
Metabolic pathways |
237 |
|
Genes shared at least 5 GO terms with CHPF (count: 11)
Genes shared at least 2 KEGG pathways with CHPF (count: 3)
View in gBrowse