ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MGAT1
Previous Symbol	MGAT, GLYT1
Symbol Alias	GNT-1, GLCNAC-TI
Approved Name	mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
Location	5
Position	chr5:180217541-180242652, -
External Links	HGNC: 7044 Entrez Gene: 4245 Ensembl: ENSG00000131446 UCSC: uc003mmg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006486	protein glycosylation	Biological Process	TAS[1702225]	15
GO:0008375	acetylglucosaminyltransferase activity	Molecular Function	TAS[1702225]	2
GO:0005975	carbohydrate metabolic process	Biological Process	TAS[1702225]	50
GO:0006049	UDP-N-acetylglucosamine catabolic process	Biological Process		1
GO:0043687	post-translational protein modification	Biological Process		37
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0046872	metal ion binding	Molecular Function		170
GO:0016021	integral to membrane	Cellular Component		845
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0001701	in utero embryonic development	Biological Process		32
GO:0003827	alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity	Molecular Function		1
GO:0000139	Golgi membrane	Cellular Component		95

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with MGAT1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
B4GALT4	7	carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; metal ion binding; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
B4GALT6	7	carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; metal ion binding; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
MAN2A2	6	carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
LMAN1	6	post-translational protein modification; cellular protein metabolic process; metal ion binding; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
MGAT4B	6	post-translational protein modification; cellular protein metabolic process; metal ion binding; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
B3GAT1	5	protein glycosylation; carbohydrate metabolic process; metal ion binding; integral to membrane; Golgi membrane;
ST8SIA3	5	protein glycosylation; post-translational protein modification; cellular protein metabolic process; protein N-linked glycosylation via asparagine; Golgi membrane;
ST3GAL4	5	carbohydrate metabolic process; post-translational protein modification; cellular protein metabolic process; protein N-linked glycosylation via asparagine; Golgi membrane;
FURIN	5	post-translational protein modification; cellular protein metabolic process; metal ion binding; integral to membrane; Golgi membrane;
MAN1A1	5	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;

Genes shared at least 2 KEGG pathways with MGAT1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr5:180217541..180242652 View in gBrowse