ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MAN2A2
Symbol Alias	MANA2X, HsT19662
Approved Name	mannosidase, alpha, class 2A, member 2
Location	15q25
Position	chr15:91447420-91465815, +
External Links	HGNC: 6825 Entrez Gene: 4122 Ensembl: ENSG00000196547 UCSC: uc002bqc.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lesch KP, 2008	Trend associated SNP was mapped in this gene.	Trend

Gene related SNPs (count: 10)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2677744	Chr15:91450441(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs2002739	Chr15:91452106(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2521498	Chr15:91442152(Fwd)	downstream_gene_variant; upstream_gene_variant
rs1029420	Chr15:91441086(Fwd)	downstream_gene_variant; upstream_gene_variant
rs4773	Chr15:91463842(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs1266483	Chr15:91462406(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1266489	Chr15:91458485(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs734252	Chr15:91446472(Fwd)	5_prime_UTR_variant; NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs2106673	Chr15:91452595(Fwd)	5_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs1266492	Chr15:91456102(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; splice_region_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	No. of Genes in ADHDgene
GO:0044267	cellular protein metabolic process	Biological Process	64
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Molecular Function	1
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process	24
GO:0030246	carbohydrate binding	Molecular Function	28
GO:0043687	post-translational protein modification	Biological Process	37
GO:0006013	mannose metabolic process	Biological Process	1
GO:0005975	carbohydrate metabolic process	Biological Process	50
GO:0016021	integral to membrane	Cellular Component	845
GO:0008270	zinc ion binding	Molecular Function	323
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	Molecular Function	1
GO:0000139	Golgi membrane	Cellular Component	95

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with MAN2A2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
B4GALT4	6	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; carbohydrate metabolic process; integral to membrane; Golgi membrane;
B4GALT6	6	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; carbohydrate metabolic process; integral to membrane; Golgi membrane;
MGAT1	6	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; carbohydrate metabolic process; integral to membrane; Golgi membrane;
LMAN1	5	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; integral to membrane; Golgi membrane;
MAN1A1	5	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; integral to membrane; Golgi membrane;
MGAT4B	5	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; integral to membrane; Golgi membrane;
ST3GAL4	5	cellular protein metabolic process; protein N-linked glycosylation via asparagine; post-translational protein modification; carbohydrate metabolic process; Golgi membrane;

Genes shared at least 2 KEGG pathways with MAN2A2 (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT4B	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr15:91447420..91465815 View in gBrowse