ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0005615
Name	extracellular space
Type	Cellular Component
No. of Genes in ADHDgene	126
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 126)

Literature-origin genes (count: 17)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GPC6	glypican 6	13q32	1(0/0/1)
GPC5	glypican 5	13q32	1(0/0/1)
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11q21-q22	1(0/0/1)	TAS[1497627]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)	IDA[16597614]
FURIN	furin (paired basic amino acid cleaving enzyme)	15q26.1	1(0/0/1)	IDA[10567353]
IL16	interleukin 16 (lymphocyte chemoattractant factor)	15q26.3	1(0/0/1)
NUCB1	nucleobindin 1	19q13.33	1(0/0/1)	TAS[1520323]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[9202027]
CNTF	ciliary neurotrophic factor	11q12	1(1/0/0)	IC[12643274]
EREG	epiregulin	4q21.21	1(0/0/1)	IDA[14581411]
NPPC	natriuretic peptide C	2q24-qter	1(0/1/0)
LPL	lipoprotein lipase	8p22	1(0/0/1)	IDA[12573449]
SLIT1	slit homolog 1 (Drosophila)	10q23.3-q24	1(0/0/1)	NAS[9813312]
IL1RN	interleukin 1 receptor antagonist	2q14.2	2(1/1/0)	IDA[12483741]
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	3p22.2	1(1/0/0)
CDH13	cadherin 13, H-cadherin (heart)	16q23.3	3(1/1/1)	IDA[16873731]

Genes from other sources (count: 109)

Approved Symbol	Approved Name	Source	Evidence[PMID]
SEMA3E	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	Mapped by CNV	TAS[9515811]
APOA5	apolipoprotein A-V	Mapped by significant region	IDA[19121291]
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	Mapped by significant region	IDA[2164002]
PAPPA	pregnancy-associated plasma protein A, pappalysin 1	Mapped by significant region
IL18	interleukin 18 (interferon-gamma-inducing factor)	Mapped by significant region
IL18BP	interleukin 18 binding protein	Mapped by significant region
VNN3	vanin 3	Mapped by significant region
CA2	carbonic anhydrase II	Mapped by CNV
GIF	gastric intrinsic factor (vitamin B synthesis)	Mapped by significant region	IDA[14695536]
ACHE	acetylcholinesterase	Mapped by PBA pathway
BTC	betacellulin	Mapped by CNV
CCL19	chemokine (C-C motif) ligand 19	Mapped by LD-proxy
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	Mapped by significant region	TAS[3360803]
IGFBP2	insulin-like growth factor binding protein 2, 36kDa	Mapped by significant region	IDA[15694994]
APOA4	apolipoprotein A-IV	Mapped by significant region
CCL27	chemokine (C-C motif) ligand 27	Mapped by LD-proxy
OGN	osteoglycin	Mapped by significant region
REG3A	regenerating islet-derived 3 alpha	Mapped by CNV	TAS[8997243]
PRSS8	protease, serine, 8	Mapped by CNV
ORM2	orosomucoid 2	Mapped by significant region
SEPP1	selenoprotein P, plasma, 1	Mapped by CNV
PATE2	prostate and testis expressed 2	Mapped by significant region	IDA[18387948]
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mapped by CNV
PATE4	prostate and testis expressed 4	Mapped by significant region
SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	Mapped by significant region
VWC2L	von Willebrand factor C domain containing protein 2-like	Mapped by significant region
IL17D	interleukin 17D	Mapped by significant region
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	Mapped by significant region
SCGB1D1	secretoglobin, family 1D, member 1	Mapped by significant region	TAS[10066439]
SCGB1D2	secretoglobin, family 1D, member 2	Mapped by significant region	TAS[10066439]
IL17C	interleukin 17C	Mapped by significant region
IGF2	insulin-like growth factor 2 (somatomedin A)	Mapped by LD-proxy; Mapped by literature SNP
FKTN	fukutin	Mapped by significant region	TAS[9690476]
TNFSF15	tumor necrosis factor (ligand) superfamily, member 15	Mapped by significant region
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	Mapped by significant region
SCGB3A1	secretoglobin, family 3A, member 1	Mapped by CNV
CTGF	connective tissue growth factor	Mapped by significant region
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway
GRP	gastrin-releasing peptide	Mapped by significant region	IDA[8756537]
LAMC1	laminin, gamma 1 (formerly LAMB2)	Mapped by significant region	NAS[10964500]
SPN	sialophorin	Mapped by CNV	IDA[10899905]
ANGPTL5	angiopoietin-like 5	Mapped by significant region
PLA2G3	phospholipase A2, group III	Mapped by PBA pathway	TAS[10713052]
GREM1	gremlin 1	Mapped by CNV; Mapped by significant region	NAS[9660951]
C5	complement component 5	Mapped by significant region
ANGPTL2	angiopoietin-like 2	Mapped by significant region
WNT10A	wingless-type MMTV integration site family, member 10A	Mapped by significant region
CTF1	cardiotrophin 1	Mapped by CNV
HPX	hemopexin	Mapped by CNV	IDA[19433579]
PNLIPRP2	pancreatic lipase-related protein 2	Mapped by PBA pathway	IDA[18702514]
SOD3	superoxide dismutase 3, extracellular	Mapped by CNV
SERPING1	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	Mapped by significant region
TTR	transthyretin	Mapped by significant region
RTN3	reticulon 3	Mapped by significant region	TAS[10331947]
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	Mapped by significant region	IDA[1695900]
APOA1	apolipoprotein A-I	Mapped by significant region	IDA[19433579]
WFDC1	WAP four-disulfide core domain 1	Mapped by CNV; Mapped by significant region	NAS[10967136]
TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	Mapped by significant region	IDA[17166734]
APOL4	apolipoprotein L, 4	Mapped by CNV
PNLIPRP1	pancreatic lipase-related protein 1	Mapped by PBA pathway	IDA[19824014]
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Mapped by significant region	TAS[1673147]
ORM1	orosomucoid 1	Mapped by significant region
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP	IDA[11751414]
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	Mapped by significant region
SORD	sorbitol dehydrogenase	Mapped by CNV	TAS[6177277]
JAM3	junctional adhesion molecule 3	Mapped by significant region
MMP10	matrix metallopeptidase 10 (stromelysin 2)	Mapped by significant region	TAS[2844164]
DPEP1	dipeptidase 1 (renal)	Mapped by significant region
GFRA4	GDNF family receptor alpha 4	Mapped by CNV
FGF9	fibroblast growth factor 9 (glia-activating factor)	Mapped by significant region	IDA[8321227]
F7	coagulation factor VII (serum prothrombin conversion accelerator)	Mapped by CNV
UMOD	uromodulin	Mapped by significant region
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	Mapped by CNV; Mapped by PBA pathway
CBLN3	cerebellin 3 precursor	Mapped by significant region
CTSG	cathepsin G	Mapped by significant region
TNN	tenascin N	Mapped by significant region
APOC3	apolipoprotein C-III	Mapped by significant region	IDA[11060345]
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region
VEGFB	vascular endothelial growth factor B	Mapped by significant region	IDA[8637916]
AMBP	alpha-1-microglobulin/bikunin precursor	Mapped by significant region
FN1	fibronectin 1	Mapped by significant region
ATRN	attractin	Mapped by CNV	IDA[17261078]
INS	insulin	Mapped by literature SNP	IDA[9667398]
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	Mapped by PBA pathway	IDA[17069818]
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mapped by significant region	IDA[11159191]
C1QTNF3	C1q and tumor necrosis factor related protein 3	Mapped by significant region
MMP13	matrix metallopeptidase 13 (collagenase 3)	Mapped by significant region	TAS[8207000]
GSN	gelsolin	Mapped by PBA pathway; Mapped by significant region
IHH	Indian hedgehog	Mapped by significant region
C1QTNF4	C1q and tumor necrosis factor related protein 4	Mapped by LD-proxy
SMPDL3A	sphingomyelin phosphodiesterase, acid-like 3A	Mapped by significant region
COL15A1	collagen, type XV, alpha 1	Mapped by significant region
NPY	neuropeptide Y	Mapped by CNV; Mapped by significant region
CTRB1	chymotrypsinogen B1	Mapped by significant region
IL22RA2	interleukin 22 receptor, alpha 2	Mapped by significant region	NAS[11390453]
APOC2	apolipoprotein C-II	Mapped by PBA pathway	IDA[10727238]
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway	IDA[7060561]
BCHE	butyrylcholinesterase	Mapped by CNV
IL5RA	interleukin 5 receptor, alpha	Mapped by CNV	TAS[1495999]
ARG1	arginase, liver	Mapped by significant region
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region	IDA[9360546]; IMP[2825030]
LIPG	lipase, endothelial	Mapped by PBA pathway	IDA[10192396]
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region
C1QTNF2	C1q and tumor necrosis factor related protein 2	Mapped by significant region
TNC	tenascin C	Mapped by significant region
MEP1B	meprin A, beta	Mapped by significant region	TAS[9288916]
CTRB2	chymotrypsinogen B2	Mapped by significant region
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[3023045]
MMP20	matrix metallopeptidase 20	Mapped by significant region	TAS[9398237]