ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPY
Symbol Alias	PYY4
Approved Name	neuropeptide Y
Location	7p15.3
Position	chr7:24323782-24331484, +
External Links	HGNC: 7955 Entrez Gene: 4852 Ensembl: ENSG00000122585 UCSC: uc003sww.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lesch[2011]_6	chr7:23010000-26070000 (NCBI Build 35 (hg17))	3060000	7p15.2-7p15.3	Duplication	Paternal (affected)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005576	extracellular region	Cellular Component		240
GO:0005615	extracellular space	Cellular Component		126
GO:0005184	neuropeptide hormone activity	Molecular Function	TAS[2427515]	3
GO:0005246	calcium channel regulator activity	Molecular Function	TAS[8132547]	10
GO:0006928	cellular component movement	Biological Process	TAS[10488139]	16
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[8132547]	18
GO:0005623	cell	Cellular Component	TAS[2444979]	1
GO:0006816	calcium ion transport	Biological Process	TAS[8132547]	32
GO:0007586	digestion	Biological Process	NAS[8421707]	13
GO:0007610	behavior	Biological Process	TAS[9845072]	10
GO:0007218	neuropeptide signaling pathway	Biological Process		17
GO:0007268	synaptic transmission	Biological Process	TAS[10557353]	96
GO:0008217	regulation of blood pressure	Biological Process		8
GO:0008283	cell proliferation	Biological Process	TAS[10488139]	60
GO:0007631	feeding behavior	Biological Process	TAS[10698177]	9
GO:0008015	blood circulation	Biological Process	NAS[8421707]	12
GO:0021954	central nervous system neuron development	Biological Process		3
GO:0008343	adult feeding behavior	Biological Process		1
GO:0031175	neuron projection development	Biological Process		10
GO:0021987	cerebral cortex development	Biological Process	IEP[9067840]	11
GO:0032100	positive regulation of appetite	Biological Process		1
GO:0005102	receptor binding	Molecular Function	TAS[8132547]	61
GO:0004930	G-protein coupled receptor activity	Molecular Function	TAS[1321422]	236
GO:0001664	G-protein coupled receptor binding	Molecular Function		8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04920	Adipocytokine signaling pathway	8	Increased adipocyte volume and number are positively correla...... Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. More...

Genes shared at least 5 GO terms with NPY (count: 1)

Gene Symbol	Pathway Count	Pathway List
GRP	5	extracellular region; extracellular space; neuropeptide hormone activity; neuropeptide signaling pathway; receptor binding;

Genes shared at least 2 KEGG pathways with NPY (count: 0)

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Region: chr7:24323782..24331484 View in gBrowse