ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0045893
Name	positive regulation of transcription, DNA-dependent
Type	Biological Process
No. of Genes in ADHDgene	80
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 80)

Literature-origin genes (count: 8)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)	IDA[17500053]
SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	6p21.1-p12.3	1(0/0/1)	NAS[9787080]
CREB5	cAMP responsive element binding protein 5	7p15	1(0/0/1)	IDA[8378084]
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	2p25	1(0/1/0)
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	IDA[11980910]
ZNF423	zinc finger protein 423	16q12	1(0/0/1)	IDA[10660046]
NPAS3	neuronal PAS domain protein 3	14q12-q13	1(1/0/0)
HAS3	hyaluronan synthase 3	16q22.1	1(0/0/1)	IDA[16900089]

Genes from other sources (count: 72)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MED14	mediator complex subunit 14	Mapped by PBA pathway	IDA[10198638]
IRF8	interferon regulatory factor 8	Mapped by significant region
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region	NAS[9422764]
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region	IDA[11909962]
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region	IDA[9697705]
FOXF1	forkhead box F1	Mapped by significant region	IDA[9769171]
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[18073330]
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region
TASP1	taspase, threonine aspartase, 1	Mapped by CNV	IMP[14636557]
TP53BP1	tumor protein p53 binding protein 1	Mapped by LD-proxy; Mapped by literature SNP	NAS[9748285]
MED13	mediator complex subunit 13	Mapped by PBA pathway	IDA[10198638]
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region	IMP[15960975]
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Mapped by CNV	IDA[19343227]
MED12	mediator complex subunit 12	Mapped by PBA pathway	IDA[10198638]
MED4	mediator complex subunit 4	Mapped by PBA pathway	IDA[10198638]
HMGA1	high mobility group AT-hook 1	Mapped by PBA pathway	IMP[10428834]
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV	IDA[12586840]
PICALM	phosphatidylinositol binding clathrin assembly protein	Mapped by significant region	IDA[11425879]
ILK	integrin-linked kinase	Mapped by CNV
MAPK9	mitogen-activated protein kinase 9	Mapped by CNV
TBX1	T-box 1	Mapped by CNV	IDA[17273972]
HINFP	histone H4 transcription factor	Mapped by significant region	IDA[17163457]
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	Mapped by PBA pathway	IDA[15790729]
ZNF287	zinc finger protein 287	Mapped by significant region
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[7749983]
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region
MED1	mediator complex subunit 1	Mapped by LD-proxy; Mapped by PBA pathway	IDA[10198638]
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region	IDA[14966270]; NAS[15572661]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[9389648]
HNF1B	HNF1 homeobox B	Mapped by CNV
LGR4	leucine-rich repeat containing G protein-coupled receptor 4	Mapped by LD-proxy
MED16	mediator complex subunit 16	Mapped by PBA pathway	IDA[10198638]
IRF7	interferon regulatory factor 7	Mapped by LD-proxy	IMP[12374802]
PHF5A	PHD finger protein 5A	Mapped by PBA pathway
RSF1	remodeling and spacing factor 1	Mapped by significant region	IDA[11788598]
FEV	FEV (ETS oncogene family)	Mapped by significant region
USP22	ubiquitin specific peptidase 22	Mapped by significant region	IMP[18206973]
NUP62	nucleoporin 62kDa	Mapped by PBA pathway	IDA[15625236]
LHX1	LIM homeobox 1	Mapped by CNV
NCOA6	nuclear receptor coactivator 6	Mapped by PBA pathway	TAS[12519782]
NRIP1	nuclear receptor interacting protein 1	Mapped by PBA pathway	NAS[15572661]
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Mapped by significant region	IMP[12805222]
LRP5	low density lipoprotein receptor-related protein 5	Mapped by CNV; Mapped by significant region	IDA[17955262]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region	IDA[9169153]
NPAT	nuclear protein, ataxia-telangiectasia locus	Mapped by CNV; Mapped by significant region	IDA[18850719]
RFX6	regulatory factor X, 6	Mapped by significant region
TGFB1I1	transforming growth factor beta 1 induced transcript 1	Mapped by PBA pathway	IDA[10075738]; NAS[15572661]
ANKRD49	ankyrin repeat domain 49	Mapped by significant region	IDA[11162141]
NSD1	nuclear receptor binding SET domain protein 1	Mapped by PBA pathway	IDA[11509567]
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway	NAS[15572661]
MED17	mediator complex subunit 17	Mapped by PBA pathway; Mapped by significant region	IDA[10198638]
FZD4	frizzled family receptor 4	Mapped by significant region	IDA[17955262]
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	Mapped by significant region	NAS[2189102]
RNF20	ring finger protein 20	Mapped by significant region	IMP[16713563]
THRAP3	thyroid hormone receptor associated protein 3	Mapped by PBA pathway	IDA[10198638]
RRN3	RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)	Mapped by CNV; Mapped by significant region
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region	IMP[19847889]
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	Mapped by PBA pathway	IDA[14701856]
MED30	mediator complex subunit 30	Mapped by PBA pathway	IDA[10198638]
EBF1	early B-cell factor 1	Mapped by significant region
CRLF3	cytokine receptor-like factor 3	Mapped by CNV	IDA[19427400]
HOXA11	homeobox A11	Mapped by significant region
PSRC1	proline/serine-rich coiled-coil 1	Mapped by CNV	ISS[12427559]
LHX2	LIM homeobox 2	Mapped by significant region
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Mapped by LD-proxy	IDA[12833137]
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy
MED24	mediator complex subunit 24	Mapped by PBA pathway	IDA[10198638]
MMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	Mapped by PBA pathway	IMP[11279242]
ROR2	receptor tyrosine kinase-like orphan receptor 2	Mapped by significant region
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IDA[19282672]
RREB1	ras responsive element binding protein 1	Mapped by CNV	TAS[9305772]
ATMIN	ATM interactor	Mapped by significant region