ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0042493
Name response to drug
Type Biological Process
No. of Genes in ADHDgene  68
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 68)

Literature-origin genes (count: 24)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DRD3 dopamine receptor D3 3q13.3 8(1/7/0)
HTR6 5-hydroxytryptamine (serotonin) receptor 6 1p36-p35 2(0/2/0)
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1)
NPPC natriuretic peptide C 2q24-qter 1(0/1/0)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 6q13 13(5/8/0)
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0)
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 5p13 2(1/1/0)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
COMT catechol-O-methyltransferase 22q11.21 25(5/20/0)
OXTR oxytocin receptor 3p25 1(0/1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C Xq24 5(2/3/0) IDA[18703043]
IL1RN interleukin 1 receptor antagonist 2q14.2 2(1/1/0)
XPO1 exportin 1 (CRM1 homolog, yeast) 2p15 1(0/0/1)
ADRA1A adrenergic, alpha-1A-, receptor 8p21.2 3(2/1/0)
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5p15.3 68(42/25/1)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0)
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0)
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13q14-q21 12(6/6/0) IDA[15862800]
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0)
LPL lipoprotein lipase 8p22 1(0/0/1)
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0)
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 17q11.2 25(13/12/0)

Genes from other sources Help (count: 44)

Approved Symbol Approved Name Source Evidence[PMID]
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region
BAD BCL2-associated agonist of cell death Mapped by significant region
AACS acetoacetyl-CoA synthetase Mapped by CNV
TJP1 tight junction protein 1 (zona occludens 1) Mapped by CNV; Mapped by significant region
ARG1 arginase, liver Mapped by significant region
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 Mapped by significant region IDA[12024214]
GSTT1 glutathione S-transferase theta 1 Mapped by CNV
WFDC1 WAP four-disulfide core domain 1 Mapped by CNV; Mapped by significant region
ADORA2A adenosine A2a receptor Mapped by CNV
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region
FOSL1 FOS-like antigen 1 Mapped by significant region
APOC3 apolipoprotein C-III Mapped by significant region
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV
GATA6 GATA binding protein 6 Mapped by significant region IMP[18671946]
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region ISS[10433800]
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 Mapped by significant region
GAL galanin prepropeptide Mapped by CNV; Mapped by significant region
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mapped by CNV; Mapped by significant region TAS[1360704]
NPC1 Niemann-Pick disease, type C1 Mapped by significant region
BLMH bleomycin hydrolase Mapped by CNV; Mapped by LD-proxy
MVP major vault protein Mapped by CNV TAS[7585126]
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Mapped by CNV; Mapped by significant region TAS[8912525]
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region
ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae) Mapped by CNV
VEGFB vascular endothelial growth factor B Mapped by significant region
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 Mapped by CNV TAS[9861027]
APOA1 apolipoprotein A-I Mapped by significant region
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region
INPPL1 inositol polyphosphate phosphatase-like 1 Mapped by significant region
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Mapped by CNV; Mapped by significant region
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mapped by significant region
CCND1 cyclin D1 Mapped by significant region IEP[18291362]
NNMT nicotinamide N-methyltransferase Mapped by significant region
RAB6C RAB6C, member RAS oncogene family Mapped by significant region IDA[11054569]
EI24 etoposide induced 2.4 mRNA Mapped by significant region
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Mapped by significant region
SRP19 signal recognition particle 19kDa Mapped by LD-proxy IDA[18089836]
SS18 synovial sarcoma translocation, chromosome 18 Mapped by significant region
NCF2 neutrophil cytosolic factor 2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014