ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0048471
Name	perinuclear region of cytoplasm
Type	cellular component
No. of Genes in ADHDgene	99
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 99)

Literature-origin genes (count: 12)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
ATXN2	ataxin 2	12q23-q24.1	1(0/0/1)	IDA[17097639]
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	7q21	1(0/0/1)	ISS
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IEA
PARK2	parkin RBR E3 ubiquitin protein ligase	6q25.2-q27	1(1/0/0)	IDA[17097639]
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	21(16/5/0)	IEA
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	IDA
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	11p11.2	1(0/0/1)	IEA
BDNF	brain-derived neurotrophic factor	11p14.1	16(8/8/0)	ISS
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	22q11.22	1(0/0/1)	IEA
MOBP	myelin-associated oligodendrocyte basic protein	3p21.33	1(0/0/1)	IEA
NOS1	nitric oxide synthase 1 (neuronal)	12q24.22	1(1/0/0)	ISS[17027776]
AANAT	aralkylamine N-acetyltransferase	17q25.1	1(0/0/1)	IDA[11313340]

Genes from other sources (count: 87)

Approved Symbol	Approved Name	Source	Evidence[PMID]
RC3H2	ring finger and CCCH-type domains 2	Mapped by significant region	IEA
DGAT2	diacylglycerol O-acyltransferase 2	Mapped by significant region	ISS
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	IDA[12762840]
MAP6	microtubule-associated protein 6	Mapped by significant region	IDA[17210638]
PLA2G16	phospholipase A2, group XVI	Mapped by significant region	IEA
PICALM	phosphatidylinositol binding clathrin assembly protein	Mapped by significant region	ISS
VPS33B	vacuolar protein sorting 33 homolog B (yeast)	Mapped by LD-proxy	IDA[19109425]
SEC23A	Sec23 homolog A (S. cerevisiae)	Mapped by LD-proxy	IEA
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway	ISS
EHD3	EH-domain containing 3	Mapped by CNV	IEA
TPPP	tubulin polymerization promoting protein	Mapped by significant region; Mapped by PBA pathway	IDA[15590652]
BSPRY	B-box and SPRY domain containing	Mapped by significant region	IEA
EHD1	EH-domain containing 1	Mapped by significant region	IEA
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	Mapped by Literature SNP	ISS
SEPT12	septin 12	Mapped by significant region	IDA[18047794]
PTCH1	patched 1	Mapped by significant region	IDA[11278759]
KRT18	keratin 18	Mapped by PBA pathway	IEA
GAK	cyclin G associated kinase	Mapped by LD-proxy	IEA
UNC45A	unc-45 homolog A (C. elegans)	Mapped by LD-proxy	IEA
RAB14	RAB14, member RAS oncogene family	Mapped by significant region; Mapped by PBA pathway	ISS
DCUN1D3	DCN1, defective in cullin neddylation 1, domain containing 3	Mapped by significant region	IDA[18823379]
TYR	tyrosinase	Mapped by significant region	IDA[11092760]
EPHA5	EPH receptor A5	Mapped by CNV; Mapped by significant region	IDA[10375373]
PNPLA8	patatin-like phospholipase domain containing 8	Mapped by PBA pathway	IEA
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	Mapped by significant region	IEA
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	Mapped by CNV	IDA[15870280]
STK33	serine/threonine kinase 33	Mapped by Literature SNP	IEA
LPXN	leupaxin	Mapped by significant region	IEA
CCDC78	coiled-coil domain containing 78	Mapped by significant region	IDA
CLINT1	clathrin interactor 1	Mapped by significant region	IEA
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IDA[17959831]
PDE2A	phosphodiesterase 2A, cGMP-stimulated	Mapped by significant region	IDA[10375378]
PLN	phospholamban	Mapped by significant region	ISS
FAM168B	family with sequence similarity 168, member B	Mapped by CNV; Mapped by significant region	IEA
NRBP1	nuclear receptor binding protein 1	Mapped by PBA pathway	IEA
ALG2	ALG2, alpha-1,3/1,6-mannosyltransferase	Mapped by significant region	IDA[17196169]
GOLGA1	golgin A1	Mapped by significant region	IEA
DCTN3	dynactin 3 (p22)	Mapped by LD-proxy	IDA[9722614]
SPIRE1	spire-type actin nucleation factor 1	Mapped by CNV	IEA
TSC2	tuberous sclerosis 2	Mapped by significant region	IDA[8806680]
CYFIP1	cytoplasmic FMR1 interacting protein 1	Mapped by significant region	ISS
PLD1	phospholipase D1, phosphatidylcholine-specific	Mapped by PBA pathway	IEA
SLC2A12	solute carrier family 2 (facilitated glucose transporter), member 12	Mapped by significant region	IEA
NF2	neurofibromin 2 (merlin)	Mapped by PBA pathway	IDA[17210637]
CABP2	calcium binding protein 2	Mapped by significant region	IEA
PICK1	protein interacting with PRKCA 1	Mapped by Literature SNP	ISS
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	Mapped by CNV	IEA
NELL1	NEL-like 1 (chicken)	Mapped by CNV	IDA
RAB40C	RAB40C, member RAS oncogene family	Mapped by significant region	IEA
TPD52L1	tumor protein D52-like 1	Mapped by significant region	IDA[12963375]
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway	IEA
ACHE	acetylcholinesterase (Yt blood group)	Mapped by PBA pathway	IDA[14766237]
USP2	ubiquitin specific peptidase 2	Mapped by significant region	IEA
SORT1	sortilin 1	Mapped by CNV	IDA[11331584]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV	IEA
SLC39A13	solute carrier family 39 (zinc transporter), member 13	Mapped by LD-proxy	ISS[18985159]
TRAPPC2L	trafficking protein particle complex 2-like	Mapped by significant region	IEA
NOX4	NADPH oxidase 4	Mapped by significant region	IEA
CYFIP2	cytoplasmic FMR1 interacting protein 2	Mapped by significant region	IDA[10449408]
NMRAL1	NmrA-like family domain containing 1	Mapped by significant region	IEA
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IEA
KLHL20	kelch-like family member 20	Mapped by significant region	IEA
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region	IEA
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region	IEA
STX7	syntaxin 7	Mapped by significant region; Mapped by PBA pathway	IEA
TWF2	twinfilin actin-binding protein 2	Mapped by LD-proxy	ISS[12807912]
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	Mapped by significant region	IDA[10513816]
AATK	apoptosis-associated tyrosine kinase	Mapped by LD-proxy	IEA
OPTN	optineurin	Mapped by PBA pathway	IEA
OBSL1	obscurin-like 1	Mapped by significant region	TAS[17289344]
STK16	serine/threonine kinase 16	Mapped by significant region	IEA
GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	Mapped by significant region	IDA[12506059]
STX6	syntaxin 6	Mapped by significant region	IDA[10506127]
GSN	gelsolin	Mapped by significant region; Mapped by PBA pathway	IEA
SYT4	synaptotagmin IV	Mapped by significant region	IEA
ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2	Mapped by LD-proxy	IEA
STX4	syntaxin 4	Mapped by CNV	IEA
PRDX5	peroxiredoxin 5	Mapped by significant region	IDA[10095767]
CALN1	calneuron 1	Mapped by CNV	IEA
GDPD5	glycerophosphodiester phosphodiesterase domain containing 5	Mapped by significant region	IEA
MAP7	microtubule-associated protein 7	Mapped by significant region; Mapped by PBA pathway	IEA
NPC1	Niemann-Pick disease, type C1	Mapped by significant region	IDA[12554680]
CTGF	connective tissue growth factor	Mapped by significant region	IEA
AXIN1	axin 1	Mapped by significant region	IDA[19038973]
SIPA1	signal-induced proliferation-associated 1	Mapped by significant region	IEA
CEP250	centrosomal protein 250kDa	Mapped by PBA pathway	IEA
TLR4	toll-like receptor 4	Mapped by significant region	IDA[15027902]