ADHDgene Database

Gene Report

Basic Info

Approved Symbol	GALNT1
Symbol Alias	GalNAc-T1
Approved Name	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
Name Alias	protein-UDP acetylgalactosaminyltransferase 1
Location	18q12.1
Position	chr18:33161003-33291798, +
External Links	HGNC: 4123 Entrez Gene: 2589 Ensembl: ENSG00000141429 UCSC: uc002kzb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[12506059]	87
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0030145	manganese ion binding	Molecular Function	IDA[9295285]	10
GO:0018243	protein O-linked glycosylation via threonine	Biological Process	IDA[9295285]	1
GO:0043687	post-translational protein modification	Biological Process		37
GO:0032580	Golgi cisterna membrane	Cellular Component		18
GO:0006493	protein O-linked glycosylation	Biological Process	TAS[9592121]	2
GO:0016021	integral to membrane	Cellular Component		845
GO:0016266	O-glycan processing	Biological Process		5
GO:0018242	protein O-linked glycosylation via serine	Biological Process	IDA[9295285]	1
GO:0000139	Golgi membrane	Cellular Component		95
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity	Molecular Function	IDA[9295285]	4
GO:0005576	extracellular region	Cellular Component		240
GO:0005794	Golgi apparatus	Cellular Component	IDA[12506059]	157

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00512	Mucin type O-Glycan biosynthesis	5	O-glycans are a class of glycans that modify serine or threo...... O-glycans are a class of glycans that modify serine or threonine residues of proteins. Biosynthesis of O-glycans starts from the transfer of N-acetylgalactosamine (GalNAc) to serine or threonine. The first GalNAc may be extended with sugars including galactose, N-acetylglucosamine, fucose, or sialic acid, but not mannose, glucose, or xylose. Depending on the sugars added, there are four common O-glycan core structures, cores 1 through 4, and an additional four, cores 5 though 8. Mucins are highly O-glycosylated glycoproteins ubiquitous in mucous secretions on cell surfaces and in body fluids. Mucin O-glycans can be branched, and many sugars or groups of sugars are antigenic. Important modifications of mucin O-glycans include O-acetylation of sialic acid and O-sulfation of galactose and N-acetylglucosamine. More...

Genes shared at least 5 GO terms with GALNT1 (count: 6)

Gene Symbol	Pathway Count	Pathway List
GALNT12	6	cellular protein metabolic process; post-translational protein modification; integral to membrane; O-glycan processing; Golgi membrane; polypeptide N-acetylgalactosaminyltransferase activity;
GALNT13	6	cellular protein metabolic process; post-translational protein modification; integral to membrane; O-glycan processing; Golgi membrane; polypeptide N-acetylgalactosaminyltransferase activity;
ST3GAL4	6	cellular protein metabolic process; post-translational protein modification; Golgi cisterna membrane; O-glycan processing; Golgi membrane; extracellular region;
B3GNT6	5	cellular protein metabolic process; post-translational protein modification; integral to membrane; O-glycan processing; Golgi membrane;
B4GALT4	5	cellular protein metabolic process; post-translational protein modification; Golgi cisterna membrane; integral to membrane; Golgi membrane;
B4GALT6	5	cellular protein metabolic process; post-translational protein modification; Golgi cisterna membrane; integral to membrane; Golgi membrane;

Genes shared at least 2 KEGG pathways with GALNT1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
B3GNT6	2	Metabolic pathways; Mucin type O-Glycan biosynthesis;
GALNT12	2	Metabolic pathways; Mucin type O-Glycan biosynthesis;
GALNT13	2	Metabolic pathways; Mucin type O-Glycan biosynthesis;
WBSCR17	2	Metabolic pathways; Mucin type O-Glycan biosynthesis;

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Region: chr18:33161003..33291798 View in gBrowse