ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SPIRE1
Symbol Alias	spir-1, KIAA1135
Approved Name	spire homolog 1 (Drosophila)
Location	18p11.21
Position	chr18:12446511-12658133, -
External Links	HGNC: 30622 Entrez Gene: 56907 Ensembl: ENSG00000134278 UCSC: uc002kre.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_194	chr18:12404326-12726491 (NCBI Build 35 (hg17))	322166	18p11.21	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005938	cell cortex	Cellular Component	26
GO:0032154	cleavage furrow	Cellular Component	8
GO:0005856	cytoskeleton	Cellular Component	54
GO:0030659	cytoplasmic vesicle membrane	Cellular Component	18
GO:0030036	actin cytoskeleton organization	Biological Process	21
GO:0040038	polar body extrusion after meiotic divisions	Biological Process	2
GO:0016192	vesicle-mediated transport	Biological Process	28
GO:0036089	cleavage furrow formation	Biological Process	2
GO:0048471	perinuclear region of cytoplasm	Cellular Component	87
GO:0046907	intracellular transport	Biological Process	6
GO:0003779	actin binding	Molecular Function	46
GO:0070649	formin-nucleated actin cable assembly	Biological Process	2
GO:0051295	establishment of meiotic spindle localization	Biological Process	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04320	Dorso-ventral axis formation	6

Genes shared at least 5 GO terms with SPIRE1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
SPIRE2	12	cell cortex; cleavage furrow; cytoskeleton; cytoplasmic vesicle membrane; actin cytoskeleton organization; polar body extrusion after meiotic divisions; vesicle-mediated transport; cleavage furrow formation; intracellular transport; actin binding; formin-nucleated actin cable assembly; establishment of meiotic spindle localization;

Genes shared at least 2 KEGG pathways with SPIRE1 (count: 0)

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Region: chr18:12446511..12658133 View in gBrowse