ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0009986
Name	cell surface
Type	Cellular Component
No. of Genes in ADHDgene	70
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 70)

Literature-origin genes (count: 12)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
LPL	lipoprotein lipase	8p22	1(0/0/1)
NRXN1	neurexin 1	2p16.3	1(0/1/0)
SLC6A1	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	3p25-p24	1(0/1/0)
ANK3	ankyrin 3, node of Ranvier (ankyrin G)	10q21	1(0/1/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	5p13	2(1/1/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	16p13.2	3(1/2/0)
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	1(1/0/0)
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	12p12	1(1/0/0)
PTPRJ	protein tyrosine phosphatase, receptor type, J	11p11.2	1(0/1/0)	IDA[12913111]
FURIN	furin (paired basic amino acid cleaving enzyme)	15q26.1	1(0/0/1)	IDA[16537537]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[17470632]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)	IDA[16597614]; NAS[11923311]

Genes from other sources (count: 58)

Approved Symbol	Approved Name	Source	Evidence[PMID]
DCBLD2	discoidin, CUB and LCCL domain containing 2	Mapped by CNV	IDA[11447234]
DSCAML1	Down syndrome cell adhesion molecule like 1	Mapped by significant region	IDA[11453658]
CCR5	chemokine (C-C motif) receptor 5	Mapped by PBA pathway	IDA[10521508]
FAM89B	family with sequence similarity 89, member B	Mapped by significant region
CNTNAP2	contactin associated protein-like 2	Mapped by CNV	IDA[19706678]
TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	Mapped by significant region	IDA[18397322]
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	Mapped by LD-proxy
STRC	stereocilin	Mapped by LD-proxy
ADAM8	ADAM metallopeptidase domain 8	Mapped by CNV; Mapped by LD-proxy	IDA[17548643]
RTN4RL2	reticulon 4 receptor-like 2	Mapped by significant region
FUT4	fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)	Mapped by significant region
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IDA[18276111]
RTN4R	reticulon 4 receptor	Mapped by CNV
AQP11	aquaporin 11	Mapped by significant region	IDA[16650285]
TIGIT	T cell immunoreceptor with Ig and ITIM domains	Mapped by LD-proxy	IDA[19011627]
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mapped by significant region	IDA[12493773]
SCARB1	scavenger receptor class B, member 1	Mapped by CNV
RC3H2	ring finger and CCCH-type domains 2	Mapped by significant region	IDA[10938276]
KLHL20	kelch-like 20 (Drosophila)	Mapped by significant region	IDA[12493773]
AAMP	angio-associated, migratory cell protein	Mapped by significant region	IDA[10329261]
NLGN1	neuroligin 1	Mapped by CNV
CXCR2	chemokine (C-X-C motif) receptor 2	Mapped by significant region	IDA[10878382]
WNT6	wingless-type MMTV integration site family, member 6	Mapped by significant region
GPRC6A	G protein-coupled receptor, family C, group 6, member A	Mapped by CNV; Mapped by significant region
NCAM1	neural cell adhesion molecule 1	Mapped by significant region	IDA[10766765]
SPN	sialophorin	Mapped by CNV
APOA4	apolipoprotein A-IV	Mapped by significant region	IDA[1935934]
FZD4	frizzled family receptor 4	Mapped by significant region	IDA[19643732]
HSPA8	heat shock 70kDa protein 8	Mapped by significant region	IDA[12493773]
CD6	CD6 molecule	Mapped by significant region	IDA[12493773]
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region	IDA[8137822]
GREM1	gremlin 1	Mapped by CNV; Mapped by significant region
PRLR	prolactin receptor	Mapped by significant region	IDA[10585417]
SORT1	sortilin 1	Mapped by CNV	IDA[10085125]
CTSG	cathepsin G	Mapped by significant region
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7	Mapped by LD-proxy
AMBP	alpha-1-microglobulin/bikunin precursor	Mapped by significant region
SLC46A2	solute carrier family 46, member 2	Mapped by significant region
TNN	tenascin N	Mapped by significant region
PDIA3	protein disulfide isomerase family A, member 3	Mapped by PBA pathway	IDA[19995400]
ERP44	endoplasmic reticulum protein 44	Mapped by significant region	IDA[19995400]
CAV3	caveolin 3	Mapped by LD-proxy; Mapped by literature SNP
ACHE	acetylcholinesterase	Mapped by PBA pathway
MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mapped by CNV	IDA[12782713]
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway
TRPV2	transient receptor potential cation channel, subfamily V, member 2	Mapped by significant region
TNR	tenascin R (restrictin, janusin)	Mapped by significant region
TNFSF18	tumor necrosis factor (ligand) superfamily, member 18	Mapped by significant region
LPAR1	lysophosphatidic acid receptor 1	Mapped by significant region	IDA[19306925]
BACE1	beta-site APP-cleaving enzyme 1	Mapped by significant region
MMP16	matrix metallopeptidase 16 (membrane-inserted)	Mapped by CNV
LAYN	layilin	Mapped by significant region
TRPC4	transient receptor potential cation channel, subfamily C, member 4	Mapped by PBA pathway	IDA[19996314]
ADAM17	ADAM metallopeptidase domain 17	Mapped by significant region	IDA[18625725]
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IDA[12493773]
CRYAB	crystallin, alpha B	Mapped by significant region
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mapped by significant region	IDA[10513816]
STX4	syntaxin 4	Mapped by CNV	IDA[15576373]