ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0006468
Name	protein phosphorylation
Type	Biological Process
No. of Genes in ADHDgene	53
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 53)

Literature-origin genes (count: 6)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IDA[11035810]
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)	TAS[9747029]
CSNK1E	casein kinase 1, epsilon	22q13.1	2(1/1/0)
GRM5	glutamate receptor, metabotropic 5	11q14.3	2(1/0/1)
BMPR1B	bone morphogenetic protein receptor, type IB	4q23-q24	1(0/0/1)	IDA[12065756]
PRKG1	protein kinase, cGMP-dependent, type I	10q11.2	1(0/0/1)	TAS[10851246]

Genes from other sources (count: 47)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CFL1	cofilin 1 (non-muscle)	Mapped by significant region
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	Mapped by significant region	IDA[15194684]; NAS[9341881]
PLK1	polo-like kinase 1	Mapped by significant region	IDA[19468300]
WNK2	WNK lysine deficient protein kinase 2	Mapped by significant region
SYK	spleen tyrosine kinase	Mapped by significant region
AURKC	aurora kinase C	Mapped by LD-proxy	IDA[15670791]
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region	IDA[18559669]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[12065756]
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV	IDA[7687743]
FES	feline sarcoma oncogene	Mapped by LD-proxy	TAS[6183005]
MARK4	MAP/microtubule affinity-regulating kinase 4	Mapped by PBA pathway	TAS[14594945]
MAML1	mastermind-like 1 (Drosophila)	Mapped by CNV	IDA[16510869]
CAMK2D	calcium/calmodulin-dependent protein kinase II delta	Mapped by CNV	IDA[17179159]
FRK	fyn-related kinase	Mapped by significant region	TAS[7696183]
FASTK	Fas-activated serine/threonine kinase	Mapped by LD-proxy; Mapped by literature SNP	IDA[7544399]
STK36	serine/threonine kinase 36	Mapped by significant region	TAS[10806483]
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	Mapped by CNV	IDA[9852112]
FYB	FYN binding protein	Mapped by significant region	TAS[9207119]
TSSK2	testis-specific serine kinase 2	Mapped by CNV
SGK1	serum/glucocorticoid regulated kinase 1	Mapped by significant region	TAS[9114008]
POLR2G	polymerase (RNA) II (DNA directed) polypeptide G	Mapped by significant region	IDA[9852112]
ERN2	endoplasmic reticulum to nucleus signaling 2	Mapped by significant region	IDA[11175748]
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	Mapped by PBA pathway	IDA[10518011]
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	Mapped by significant region	IDA[9792677]
PHKG2	phosphorylase kinase, gamma 2 (testis)	Mapped by CNV
IRF7	interferon regulatory factor 7	Mapped by LD-proxy	IDA[12374802]
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	IDA[11053428]
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region	IDA[12840024]
MARK2	MAP/microtubule affinity-regulating kinase 2	Mapped by significant region	IDA[14976552]; NAS[8274451]
CDC25B	cell division cycle 25 homolog B (S. pombe)	Mapped by CNV	IDA[17332740]
TSSK4	testis-specific serine kinase 4	Mapped by significant region	IDA[15964553]
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV	TAS[18329369]
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	Mapped by significant region	NAS[7514601]
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	Mapped by significant region	IDA[11784851]
LIPE	lipase, hormone-sensitive	Mapped by PBA pathway	TAS[3420405]
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region
PRKCB	protein kinase C, beta	Mapped by significant region	TAS[3755548]
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	Mapped by significant region	TAS[9751059]
ROS1	c-ros oncogene 1 , receptor tyrosine kinase	Mapped by significant region	IDA[16885344]
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy	TAS[10851066]
SIK2	salt-inducible kinase 2	Mapped by significant region	IDA[14976552]
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region	IDA[17028174]
ILK	integrin-linked kinase	Mapped by CNV	IDA[10871859]
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	Mapped by significant region
SIK3	SIK family kinase 3	Mapped by significant region	IDA[14976552]
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	Mapped by significant region	IDA[10871863]
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region	IDA[9852149]