ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0043565
Name sequence-specific DNA binding
Type molecular function
No. of Genes in ADHDgene  80
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 80)

Literature-origin genes (count: 11)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
FOXP2 forkhead box P2 7q31 1(1/0/0) IDA[18987363]
MEIS2 Meis homeobox 2 15q14 1(0/0/1) IDA[17178831]; IEA
CREB5 cAMP responsive element binding protein 5 7p15 1(0/0/1) IEA
HOXB1 homeobox B1 17q21.32 1(0/0/1) IEA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) IEA
DMRT2 doublesex and mab-3 related transcription factor 2 9p24.3 1(0/0/1) IEA
NR3C2 nuclear receptor subfamily 3, group C, member 2 4q31 1(0/1/0) IEA
ETV5 ets variant 5 3q28 1(1/0/0) IEA
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) ISS
FOXP1 forkhead box P1 3p14.1 1(0/0/1) IEA
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA[12169688]

Genes from other sources Help (count: 69)

Approved Symbol Approved Name Source Evidence[PMID]
NANOGP1 Nanog homeobox pseudogene 1 Mapped by CNV IEA
EVX1 even-skipped homeobox 1 Mapped by significant region IEA
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region IEA
HOXA5 homeobox A5 Mapped by significant region IEA
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit Mapped by significant region IEA
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 Mapped by significant region IDA[11486045]
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Mapped by significant region IEA
FOXR1 forkhead box R1 Mapped by significant region IEA
FOXE1 forkhead box E1 (thyroid transcription factor 2) Mapped by significant region IEA
FEV FEV (ETS oncogene family) Mapped by significant region IEA
NFE2L3 nuclear factor, erythroid 2-like 3 Mapped by CNV; Mapped by significant region IEA
LMX1B LIM homeobox transcription factor 1, beta Mapped by significant region IEA
HOXA10 homeobox A10 Mapped by significant region IEA
HOXA7 homeobox A7 Mapped by significant region IDA[11435435]
LHX6 LIM homeobox 6 Mapped by significant region IEA
ESRRA estrogen-related receptor alpha Mapped by significant region IEA
MTA2 metastasis associated 1 family, member 2 Mapped by significant region IEA
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 Mapped by significant region IEA
GSC2 goosecoid homeobox 2 Mapped by CNV IEA
HOXA1 homeobox A1 Mapped by significant region IEA
IKZF1 IKAROS family zinc finger 1 (Ikaros) Mapped by LD-proxy IEA
FOXD4 forkhead box D4 Mapped by CNV ISS[7957066]
IRX3 iroquois homeobox 3 Mapped by CNV IEA
HOXA11 homeobox A11 Mapped by significant region IEA
BATF2 basic leucine zipper transcription factor, ATF-like 2 Mapped by significant region IEA
FOXF1 forkhead box F1 Mapped by significant region ISS[7957066]
BSX brain-specific homeobox Mapped by significant region IEA
PRDM1 PR domain containing 1, with ZNF domain Mapped by CNV IEA
POU2F3 POU class 2 homeobox 3 Mapped by significant region IDA[9242494]
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) Mapped by significant region IDA[2123466]
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IEA
RAX retina and anterior neural fold homeobox Mapped by LD-proxy; Mapped by significant region IEA
HNF1B HNF1 homeobox B Mapped by CNV IEA
FOXG1 forkhead box G1 Mapped by significant region IEA
LHX2 LIM homeobox 2 Mapped by significant region IEA
GATAD2A GATA zinc finger domain containing 2A Mapped by LD-proxy IEA
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Mapped by significant region IDA[16081467]
NR5A1 nuclear receptor subfamily 5, group A, member 1 Mapped by significant region IEA
SOX30 SRY (sex determining region Y)-box 30 Mapped by significant region IDA[10359848]
PRDM9 PR domain containing 9 Mapped by significant region IEA
ATF6 activating transcription factor 6 Mapped by CNV IEA
RORA RAR-related orphan receptor A Mapped by Literature SNP IEA
ZNF24 zinc finger protein 24 Mapped by significant region ISS
PGR progesterone receptor Mapped by significant region IEA
HOXA4 homeobox A4 Mapped by significant region IEA
HOXA3 homeobox A3 Mapped by significant region IEA
PBX3 pre-B-cell leukemia homeobox 3 Mapped by significant region IEA
ONECUT2 one cut homeobox 2 Mapped by significant region IEA
ZEB2 zinc finger E-box binding homeobox 2 Mapped by PBA pathway IEA
HOXA6 homeobox A6 Mapped by significant region IEA
HOXA9 homeobox A9 Mapped by significant region IEA
PKNOX2 PBX/knotted 1 homeobox 2 Mapped by significant region IEA
ZSCAN10 zinc finger and SCAN domain containing 10 Mapped by significant region ISS
LHX1 LIM homeobox 1 Mapped by CNV IEA
MEN1 multiple endocrine neoplasia I Mapped by significant region IEA
HOXA2 homeobox A2 Mapped by significant region IEA
CREBZF CREB/ATF bZIP transcription factor Mapped by significant region IEA
CENPB centromere protein B, 80kDa Mapped by CNV TAS[11682612]
NR6A1 nuclear receptor subfamily 6, group A, member 1 Mapped by significant region ISS
TSHZ2 teashirt zinc finger homeobox 2 Mapped by Literature SNP IEA
MTA3 metastasis associated 1 family, member 3 Mapped by Literature SNP IEA
IRX2 iroquois homeobox 2 Mapped by significant region IEA
FOXL1 forkhead box L1 Mapped by significant region IDA[7957066]
HOXA13 homeobox A13 Mapped by significant region IEA
IRX4 iroquois homeobox 4 Mapped by significant region IEA
TBX1 T-box 1 Mapped by CNV IDA[11111039]
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) Mapped by significant region IEA
VENTX VENT homeobox Mapped by CNV IEA
IRX1 iroquois homeobox 1 Mapped by significant region IEA