ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0008285
Name	negative regulation of cell proliferation
Type	Biological Process
No. of Genes in ADHDgene	59
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 59)

Literature-origin genes (count: 10)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
EREG	epiregulin	4q21.21	1(0/0/1)
NPPC	natriuretic peptide C	2q24-qter	1(0/1/0)
DRD2	dopamine receptor D2	11q22-q23	10(3/7/0)
CDH13	cadherin 13, H-cadherin (heart)	16q23.3	3(1/1/1)	IDA[10737605]
OPRM1	opioid receptor, mu 1	6q24-q25	1(1/0/0)	TAS[2159143]
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)	TAS[10860850]
PTPRJ	protein tyrosine phosphatase, receptor type, J	11p11.2	1(0/1/0)	IDA[14709717]
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	7q21	1(0/0/1)
KANK2	KN motif and ankyrin repeat domains 2	19p13.2	1(0/1/0)	IDA[17476305]
FGF10	fibroblast growth factor 10	5p13-p12	1(0/1/0)

Genes from other sources (count: 49)

Approved Symbol	Approved Name	Source	Evidence[PMID]
FABP6	fatty acid binding protein 6, ileal	Mapped by significant region	TAS[9250612]
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region
RARRES3	retinoic acid receptor responder (tazarotene induced) 3	Mapped by significant region	TAS[9843971]
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region
HMGA1	high mobility group AT-hook 1	Mapped by PBA pathway	IMP[16901784]
ADORA2A	adenosine A2a receptor	Mapped by CNV
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IDA[18276111]
FABP7	fatty acid binding protein 7, brain	Mapped by significant region	TAS[9250612]
NOX4	NADPH oxidase 4	Mapped by significant region	ISS[10869423]
TSC1	tuberous sclerosis 1	Mapped by PBA pathway	IMP[10915759]
WNK2	WNK lysine deficient protein kinase 2	Mapped by significant region	IMP[17667937]
GPNMB	glycoprotein (transmembrane) nmb	Mapped by CNV; Mapped by significant region	TAS[7814155]
GJA1	gap junction protein, alpha 1, 43kDa	Mapped by significant region
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region	TAS[2187191]
FOSL1	FOS-like antigen 1	Mapped by significant region
DFNA5	deafness, autosomal dominant 5	Mapped by CNV; Mapped by significant region	IDA[18223688]
MEN1	multiple endocrine neoplasia I	Mapped by significant region	IDA[15331604]
FRK	fyn-related kinase	Mapped by significant region	TAS[7664264]
NCK2	NCK adaptor protein 2	Mapped by PBA pathway	TAS[9737977]
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	Mapped by significant region	IGI[9553041]
NUP62	nucleoporin 62kDa	Mapped by PBA pathway	IDA[11013214]
UMOD	uromodulin	Mapped by significant region	TAS[2409603]
CDK10	cyclin-dependent kinase 10	Mapped by significant region	TAS[8208557]
ROR2	receptor tyrosine kinase-like orphan receptor 2	Mapped by significant region	IMP[19486338]
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Mapped by CNV
BTG4	B-cell translocation gene 4	Mapped by significant region	TAS[10995567]
NDN	necdin homolog (mouse)	Mapped by CNV; Mapped by significant region	TAS[9630521]
PTPN14	protein tyrosine phosphatase, non-receptor type 14	Mapped by literature SNP
ENPP7	ectonucleotide pyrophosphatase/phosphodiesterase 7	Mapped by PBA pathway	IDA[12671034]
SPEG	SPEG complex locus	Mapped by significant region	TAS[8663449]
DIS3L2	DIS3 mitotic control homolog (S. cerevisiae)-like 2	Mapped by LD-proxy
ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	Mapped by significant region	TAS[10438512]
GAS8	growth arrest-specific 8	Mapped by significant region	TAS[9790751]
SKAP2	src kinase associated phosphoprotein 2	Mapped by significant region
FTH1	ferritin, heavy polypeptide 1	Mapped by significant region
TBRG1	transforming growth factor beta regulator 1	Mapped by significant region	IMP[17110379]
KLF11	Kruppel-like factor 11	Mapped by significant region
CUL5	cullin 5	Mapped by PBA pathway; Mapped by significant region	TAS[8681378]
FKTN	fukutin	Mapped by significant region	IMP[18808525]
TMEM127	transmembrane protein 127	Mapped by LD-proxy
KLF13	Kruppel-like factor 13	Mapped by CNV; Mapped by significant region
INPPL1	inositol polyphosphate phosphatase-like 1	Mapped by significant region
NF2	neurofibromin 2 (merlin)	Mapped by PBA pathway	IDA[12444102]; IMP[17210637]
DEC1	deleted in esophageal cancer 1	Mapped by significant region	TAS[10612805]
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region	TAS[8702718]
PRKRIR	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	Mapped by significant region	TAS[9447982]
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway	IDA[8521819]
TGFB1I1	transforming growth factor beta 1 induced transcript 1	Mapped by PBA pathway	TAS[7929412]