ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0043025
Name	neuronal cell body
Type	Cellular Component
No. of Genes in ADHDgene	51
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 51)

Literature-origin genes (count: 17)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p11	6(5/1/0)
NRSN1	neurensin 1	6p22.1	1(1/0/0)
CHRNA3	cholinergic receptor, nicotinic, alpha 3	15q24	1(0/1/0)
SLC5A7	solute carrier family 5 (choline transporter), member 7	2q12	1(1/0/0)
CHRNA4	cholinergic receptor, nicotinic, alpha 4	20	7(4/3/0)
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	17	1(0/1/0)
SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	10q25	2(0/2/0)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	5p13	2(1/1/0)
SNPH	syntaphilin	20p13	1(1/0/0)
CPLX1	complexin 1	4p16.3	1(1/0/0)
CPLX2	complexin 2	5q35.2	2(1/0/1)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	5p15.3	68(42/25/1)	IDA[12958153]
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	1(1/0/0)
DRD4	dopamine receptor D4	11p15.5	67(49/18/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	1(0/1/0)
KCNIP4	Kv channel interacting protein 4	4p15.32	1(1/0/0)

Genes from other sources (count: 34)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ILK	integrin-linked kinase	Mapped by CNV
GRIN3A	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	Mapped by significant region	IDA[17658481]
CANX	calnexin	Mapped by CNV
P2RX6	purinergic receptor P2X, ligand-gated ion channel, 6	Mapped by CNV
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	Mapped by significant region
EPHA5	EPH receptor A5	Mapped by CNV; Mapped by significant region	IDA[10375373]
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
ADORA2A	adenosine A2a receptor	Mapped by CNV
ARG1	arginase, liver	Mapped by significant region
RTN4	reticulon 4	Mapped by CNV
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region
INHA	inhibin, alpha	Mapped by significant region
CAMK2D	calcium/calmodulin-dependent protein kinase II delta	Mapped by CNV
NCAM1	neural cell adhesion molecule 1	Mapped by significant region
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway
TXN	thioredoxin	Mapped by significant region
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	ISS[15528209]
KLHL14	kelch-like 14 (Drosophila)	Mapped by significant region
KATNB1	katanin p80 (WD repeat containing) subunit B 1	Mapped by PBA pathway
KLHL1	kelch-like 1 (Drosophila)	Mapped by CNV
CNTNAP2	contactin associated protein-like 2	Mapped by CNV
UBXN1	UBX domain protein 1	Mapped by significant region
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	Mapped by CNV
SORT1	sortilin 1	Mapped by CNV
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region
SPTBN2	spectrin, beta, non-erythrocytic 2	Mapped by significant region
CYBA	cytochrome b-245, alpha polypeptide	Mapped by significant region
STRN3	striatin, calmodulin binding protein 3	Mapped by significant region
OMP	olfactory marker protein	Mapped by significant region
TMPRSS5	transmembrane protease, serine 5	Mapped by significant region
DIXDC1	DIX domain containing 1	Mapped by significant region
KCNIP1	Kv channel interacting protein 1	Mapped by LD-proxy; Mapped by literature SNP
FABP7	fatty acid binding protein 7, brain	Mapped by significant region
DENND1A	DENN/MADD domain containing 1A	Mapped by significant region