ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004674
Name	protein serine/threonine kinase activity
Type	Molecular Function
No. of Genes in ADHDgene	61
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 61)

Literature-origin genes (count: 7)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)
DCLK2	doublecortin-like kinase 2	4q31.3	1(0/0/1)
CSNK1E	casein kinase 1, epsilon	22q13.1	2(1/1/0)	TAS[7797465]
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)
BMPR1B	bone morphogenetic protein receptor, type IB	4q23-q24	1(0/0/1)	IDA[12065756]
TRIO	triple functional domain (PTPRF interacting)	5p14-p15.1	1(0/0/1)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IDA[11035810]

Genes from other sources (count: 54)

Approved Symbol	Approved Name	Source	Evidence[PMID]
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region	IDA[16278681]
PRKD1	protein kinase D1	Mapped by significant region	IDA[18440775]; TAS[8119958]
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	Mapped by significant region	IDA[15194684]; NAS[9341881]
TAOK2	TAO kinase 2	Mapped by CNV	IDA[11279118]
WNK2	WNK lysine deficient protein kinase 2	Mapped by significant region
PLK1	polo-like kinase 1	Mapped by significant region	IDA[19468302]
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region	IDA[16574662]
AURKC	aurora kinase C	Mapped by LD-proxy
ATM	ataxia telangiectasia mutated	Mapped by CNV; Mapped by significant region	IDA[9733515]
MARK4	MAP/microtubule affinity-regulating kinase 4	Mapped by PBA pathway	IDA[15009667]
RIPK3	receptor-interacting serine-threonine kinase 3	Mapped by significant region	TAS[10339433]
FASTK	Fas-activated serine/threonine kinase	Mapped by LD-proxy; Mapped by literature SNP	IDA[7544399]
RIOK3	RIO kinase 3 (yeast)	Mapped by significant region
SMG1	smg-1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	Mapped by significant region	IDA[19417104]; NAS[11331269]
STK32C	serine/threonine kinase 32C	Mapped by CNV
CHEK1	CHK1 checkpoint homolog (S. pombe)	Mapped by significant region	IDA[16963448]
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy	IDA[15850461]
PHKG2	phosphorylase kinase, gamma 2 (testis)	Mapped by CNV	TAS[10487978]
STK36	serine/threonine kinase 36	Mapped by significant region	TAS[10806483]
STK32B	serine/threonine kinase 32B	Mapped by CNV
ERN2	endoplasmic reticulum to nucleus signaling 2	Mapped by significant region	IDA[11175748]
MYLK4	myosin light chain kinase family, member 4	Mapped by CNV
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	Mapped by PBA pathway
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	Mapped by significant region	IDA[9792677]; IMP[12773393]
TSSK4	testis-specific serine kinase 4	Mapped by significant region	IDA[15964553]
STK31	serine/threonine kinase 31	Mapped by CNV; Mapped by significant region
SGK1	serum/glucocorticoid regulated kinase 1	Mapped by significant region
SPEG	SPEG complex locus	Mapped by significant region
PSKH2	protein serine kinase H2	Mapped by CNV
MARK2	MAP/microtubule affinity-regulating kinase 2	Mapped by significant region	NAS[8274451]
ULK2	unc-51-like kinase 2 (C. elegans)	Mapped by significant region	IDA[18936157]
AATK	apoptosis-associated tyrosine kinase	Mapped by LD-proxy
TSSK2	testis-specific serine kinase 2	Mapped by CNV	IDA[18533145]
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	Mapped by CNV
STK16	serine/threonine kinase 16	Mapped by significant region
ALPK2	alpha-kinase 2	Mapped by significant region
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	IDA[8195146]
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Mapped by CNV
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Mapped by significant region	TAS[9878560]
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	Mapped by CNV
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[18625725]
BCKDK	branched chain ketoacid dehydrogenase kinase	Mapped by CNV
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	Mapped by significant region	IDA[11784851]
ILK	integrin-linked kinase	Mapped by CNV	IDA[9366252]
TTK	TTK protein kinase	Mapped by PBA pathway
CPNE3	copine III	Mapped by CNV	IDA[11041869]
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region
SIK2	salt-inducible kinase 2	Mapped by significant region	IDA[18348280]
ANKK1	ankyrin repeat and kinase domain containing 1	Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region
GAK	cyclin G associated kinase	Mapped by LD-proxy
SQSTM1	sequestosome 1	Mapped by CNV	NAS[8618896]
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	Mapped by significant region	IDA[10871863]
PRKCB	protein kinase C, beta	Mapped by significant region
SIK3	SIK family kinase 3	Mapped by significant region	IDA[14976552]