ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0019904
Name	protein domain specific binding
Type	molecular function
No. of Genes in ADHDgene	43
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 43)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
TH	tyrosine hydroxylase	11p15.5	7(2/5/0)	IEA
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)	IEA
LIN7C	lin-7 homolog C (C. elegans)	11p14	1(1/0/0)	IPI[17237226]
ARRB2	arrestin, beta 2	17p13	1(1/0/0)	IEA
HOXB1	homeobox B1	17q21.32	1(0/0/1)	IPI[10052460]
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p12.1	6(5/1/0)	IEA
DRD3	dopamine receptor D3	3q13.3	8(1/7/0)	IEA
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	IEA
XPO1	exportin 1	2p15	1(0/0/1)	IEA

Genes from other sources (count: 34)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CHMP1A	charged multivesicular body protein 1A	Mapped by significant region	IPI[17928862]
XPA	xeroderma pigmentosum, complementation group A	Mapped by significant region	IPI[17720715]
PHRF1	PHD and ring finger domains 1	Mapped by LD-proxy	IEA
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region	TAS[18421703]
RAB27A	RAB27A, member RAS oncogene family	Mapped by LD-proxy	IEA
TJP1	tight junction protein 1	Mapped by CNV; Mapped by significant region	IEA
MYO7A	myosin VIIA	Mapped by significant region	IEA
NDE1	nudE neurodevelopment protein 1	Mapped by CNV; Mapped by significant region	IEA
CTNND1	catenin (cadherin-associated protein), delta 1	Mapped by significant region	IEA
BASP1	brain abundant, membrane attached signal protein 1	Mapped by significant region	IPI[14701728]
KCTD13	potassium channel tetramerization domain containing 13	Mapped by CNV	IEA
CBX3	chromobox homolog 3	Mapped by CNV; Mapped by significant region	IPI[9636147]
ESRRA	estrogen-related receptor alpha	Mapped by significant region	IPI[11984006]
RAB6A	RAB6A, member RAS oncogene family	Mapped by CNV; Mapped by significant region	IPI[12447383]
ARFIP2	ADP-ribosylation factor interacting protein 2	Mapped by CNV	IEA
MED12	mediator complex subunit 12	Mapped by PBA pathway	IPI[11984006]
CHMP1B	charged multivesicular body protein 1B	Mapped by Literature SNP	IPI[17928862]
FAM92B	family with sequence similarity 92, member B	Mapped by significant region	IEA
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Mapped by significant region	IEA
RAB27B	RAB27B, member RAS oncogene family	Mapped by Literature SNP	IPI[16880209]
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IPI[12411443]
AKAP7	A kinase (PRKA) anchor protein 7	Mapped by significant region	IEA
STX1B	syntaxin 1B	Mapped by CNV	IEA
TACC2	transforming, acidic coiled-coil containing protein 2	Mapped by PBA pathway	IEA
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region	IPI[10947987]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV	IEA
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta	Mapped by significant region	IEA
ZNF521	zinc finger protein 521	Mapped by significant region	IPI[11984006]
NCK1	NCK adaptor protein 1	Mapped by PBA pathway	IEA
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta	Mapped by PBA pathway	ISS
PICK1	protein interacting with PRKCA 1	Mapped by Literature SNP	IEA
MRPL17	mitochondrial ribosomal protein L17	Mapped by CNV	IPI[11984006]
PKD1	polycystic kidney disease 1 (autosomal dominant)	Mapped by significant region	IPI[9171830]
CENPJ	centromere protein J	Mapped by PBA pathway	IPI[11984006]