ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0019904
Name	protein domain specific binding
Type	Molecular Function
No. of Genes in ADHDgene	40
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 40)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
XPO1	exportin 1 (CRM1 homolog, yeast)	2p15	1(0/0/1)
LIN7C	lin-7 homolog C (C. elegans)	11p14	1(1/0/0)	IPI[17237226]
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)
HOXB1	homeobox B1	17q21.32	1(0/0/1)	IPI[10052460]
TH	tyrosine hydroxylase	11p15.5	7(2/5/0)
ARRB2	arrestin, beta 2	17p13	1(1/0/0)
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p11	6(5/1/0)
DRD3	dopamine receptor D3	3q13.3	8(1/7/0)

Genes from other sources (count: 31)

Approved Symbol	Approved Name	Source	Evidence[PMID]
NCK1	NCK adaptor protein 1	Mapped by PBA pathway
FAM92B	family with sequence similarity 92, member B	Mapped by significant region
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV
CBX3	chromobox homolog 3	Mapped by CNV; Mapped by significant region	IPI[9636147]
RAB27A	RAB27A, member RAS oncogene family	Mapped by LD-proxy
MYO7A	myosin VIIA	Mapped by significant region
TACC2	transforming, acidic coiled-coil containing protein 2	Mapped by PBA pathway
TJP1	tight junction protein 1 (zona occludens 1)	Mapped by CNV; Mapped by significant region
MED12	mediator complex subunit 12	Mapped by PBA pathway	IPI[11984006]
ZNF521	zinc finger protein 521	Mapped by significant region	IPI[11984006]
STX1B	syntaxin 1B	Mapped by CNV
MRPL17	mitochondrial ribosomal protein L17	Mapped by CNV	IPI[11984006]
CHMP1B	chromatin modifying protein 1B	Mapped by literature SNP	IPI[17928862]
CHMP1A	chromatin modifying protein 1A	Mapped by significant region	IPI[17928862]
CTNND1	catenin (cadherin-associated protein), delta 1	Mapped by significant region
CENPJ	centromere protein J	Mapped by PBA pathway	IPI[11984006]
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	Mapped by PBA pathway
NDE1	nudE nuclear distribution gene E homolog 1 (A. nidulans)	Mapped by CNV; Mapped by significant region
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region	IPI[10947987]
RAB27B	RAB27B, member RAS oncogene family	Mapped by LD-proxy; Mapped by literature SNP	IPI[16880209]
ESRRA	estrogen-related receptor alpha	Mapped by significant region	IPI[11984006]
PHRF1	PHD and ring finger domains 1	Mapped by LD-proxy
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Mapped by significant region
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Mapped by significant region
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IPI[12411443]
XPA	xeroderma pigmentosum, complementation group A	Mapped by significant region	IPI[17720715]
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region	TAS[18421703]
ARFIP2	ADP-ribosylation factor interacting protein 2	Mapped by CNV
RAB6A	RAB6A, member RAS oncogene family	Mapped by CNV; Mapped by significant region	IPI[12447383]
KCTD13	potassium channel tetramerisation domain containing 13	Mapped by CNV
AKAP7	A kinase (PRKA) anchor protein 7	Mapped by significant region