ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004842
Name	ubiquitin-protein ligase activity
Type	Molecular Function
No. of Genes in ADHDgene	52
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 52)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
TRIM32	tripartite motif containing 32	9q33.1	1(0/0/1)	IDA[16816390]
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	6q25.2-q27	1(1/0/0)	IDA[16227987]

Genes from other sources (count: 50)

Approved Symbol	Approved Name	Source	Evidence[PMID]
RNF144B	ring finger protein 144B	Mapped by LD-proxy	IDA[12853982]
HERC2	hect domain and RLD 2	Mapped by significant region
FBXO7	F-box protein 7	Mapped by LD-proxy	TAS[10531035]
RCHY1	ring finger and CHY zinc finger domain containing 1	Mapped by CNV	IDA[19483087]
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	Mapped by significant region	IDA[15258597]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IDA[15125833]
RNF146	ring finger protein 146	Mapped by significant region
FBXO4	F-box protein 4	Mapped by significant region	IDA[10531035]
UBE2L6	ubiquitin-conjugating enzyme E2L 6	Mapped by significant region
HERC2P3	hect domain and RLD 2 pseudogene 3	Mapped by significant region
ANAPC4	anaphase promoting complex subunit 4	Mapped by CNV	TAS[6180011]
ZFP91	zinc finger protein 91 homolog (mouse)	Mapped by significant region
HERC3	hect domain and RLD 3	Mapped by CNV
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Mapped by significant region
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	Mapped by significant region	NAS[11244092]
HERC5	hect domain and RLD 5	Mapped by CNV
UBE3A	ubiquitin protein ligase E3A	Mapped by CNV; Mapped by significant region	IDA[12890688]
WWP1	WW domain containing E3 ubiquitin protein ligase 1	Mapped by CNV	TAS[9169421]
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	Mapped by significant region	IDA[15256501]
KCTD13	potassium channel tetramerisation domain containing 13	Mapped by CNV	IDA[19782033]
SKP2	S-phase kinase-associated protein 2 (p45)	Mapped by significant region
KLHL20	kelch-like 20 (Drosophila)	Mapped by significant region
HECTD1	HECT domain containing 1	Mapped by significant region
BIRC2	baculoviral IAP repeat containing 2	Mapped by significant region	IDA[11907583]
MIB1	mindbomb homolog 1 (Drosophila)	Mapped by significant region
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	Mapped by CNV	IDA[12732143]
PRPF19	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	Mapped by significant region	IDA[11435423]
RC3H1	ring finger and CCCH-type domains 1	Mapped by significant region	TAS[19217324]
TRIP12	thyroid hormone receptor interactor 12	Mapped by PBA pathway	IDA[18627766]; IMP[19028681]
RNF2	ring finger protein 2	Mapped by significant region	IDA[16714294]
FBXW2	F-box and WD repeat domain containing 2	Mapped by significant region	TAS[10531035]
MARCH4	membrane-associated ring finger (C3HC4) 4	Mapped by significant region	IDA[14722266]
RNF20	ring finger protein 20	Mapped by significant region	IDA[19037095,16307923]
TRIM13	tripartite motif containing 13	Mapped by LD-proxy	IDA[17314412]
RNF25	ring finger protein 25	Mapped by significant region
RNF217	ring finger protein 217	Mapped by significant region
RFWD3	ring finger and WD repeat domain 3	Mapped by significant region
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV	IDA[15200957]
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	NAS[15905410]
ZNRF1	zinc and ring finger 1	Mapped by significant region
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	Mapped by significant region
FBXO25	F-box protein 25	Mapped by CNV	NAS[10531035]
RNF130	ring finger protein 130	Mapped by CNV	IDA[16549277]
RNF31	ring finger protein 31	Mapped by significant region	IDA[17006537]
TRIM5	tripartite motif containing 5	Mapped by CNV
RNF125	ring finger protein 125	Mapped by significant region
HERC6	hect domain and RLD 6	Mapped by CNV
BRAP	BRCA1 associated protein	Mapped by LD-proxy	IDA[14724641]
RNF40	ring finger protein 40	Mapped by CNV	IDA[16307923]
BIRC3	baculoviral IAP repeat containing 3	Mapped by significant region	IDA[16395405]