ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0006357
Name	regulation of transcription from RNA polymerase II promoter
Type	Biological Process
No. of Genes in ADHDgene	42
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 42)

Literature-origin genes (count: 5)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)	TAS[10198158]
TCEB1	transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)	8q13.3	1(0/0/1)	TAS[7660129]
HES6	hairy and enhancer of split 6 (Drosophila)	2q37.3	1(0/1/0)
SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	6p21.1-p12.3	1(0/0/1)	TAS[9787080]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IMP[18093989]

Genes from other sources (count: 37)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TBX1	T-box 1	Mapped by CNV	NAS[9268629]
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	Mapped by significant region	TAS[9674425]
SUB1	SUB1 homolog (S. cerevisiae)	Mapped by significant region	IDA[8062391]
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy	IMP[16079795]
ZNF367	zinc finger protein 367	Mapped by significant region	IDA[15344908]
TBX10	T-box 10	Mapped by significant region	TAS[9545502]
SRCAP	Snf2-related CREBBP activator protein	Mapped by CNV	TAS[10347196]
UTF1	undifferentiated embryonic cell transcription factor 1	Mapped by CNV	TAS[9748258]
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Mapped by CNV	NAS[8804307]
FOSL1	FOS-like antigen 1	Mapped by significant region	TAS[10918580]
CTDSP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1	Mapped by significant region	IDA[12721286]
MED7	mediator complex subunit 7	Mapped by significant region	IDA[9989412]
HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)	Mapped by CNV	TAS[9731536]
ELP2	elongation protein 2 homolog (S. cerevisiae)	Mapped by significant region	TAS[11714725]
CIAO1	cytosolic iron-sulfur protein assembly 1	Mapped by LD-proxy	TAS[9556563]
SMARCAL1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	Mapped by significant region	IMP[18974355]
RBBP8	retinoblastoma binding protein 8	Mapped by significant region	TAS[10764811]
MED23	mediator complex subunit 23	Mapped by significant region	TAS[9989412]
MED14	mediator complex subunit 14	Mapped by PBA pathway	TAS[9989412]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region	TAS[8156598]
NEUROD2	neurogenic differentiation 2	Mapped by LD-proxy	TAS[8816493]
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	Mapped by significant region	IDA[11818576]; TAS[11714725]
DEAF1	deformed epidermal autoregulatory factor 1 (Drosophila)	Mapped by literature SNP
PKNOX2	PBX/knotted 1 homeobox 2	Mapped by significant region
SOX30	SRY (sex determining region Y)-box 30	Mapped by significant region	IDA[10359848]
SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3	Mapped by PBA pathway	IMP[17363140]; NAS[8804307]
PRKCB	protein kinase C, beta	Mapped by significant region
MED17	mediator complex subunit 17	Mapped by PBA pathway; Mapped by significant region	IDA[9989412]
SAP18	Sin3A-associated protein, 18kDa	Mapped by significant region	TAS[9150135]
MED16	mediator complex subunit 16	Mapped by PBA pathway	NAS[10198638]
ATF6	activating transcription factor 6	Mapped by CNV	TAS[10564271]
POU2F3	POU class 2 homeobox 3	Mapped by significant region	TAS[10473598]
GSC2	goosecoid homeobox 2	Mapped by CNV	IDA[9700206]
RAI1	retinoic acid induced 1	Mapped by significant region
SNW1	SNW domain containing 1	Mapped by PBA pathway	TAS[9632709]
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	Mapped by significant region
SP4	Sp4 transcription factor	Mapped by significant region	IDA[12560508]