ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0007264
Name	small GTPase mediated signal transduction
Type	Biological Process
No. of Genes in ADHDgene	58
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 58)

Literature-origin genes (count: 7)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TIAM2	T-cell lymphoma invasion and metastasis 2	6q25	1(0/0/1)
DOCK10	dedicator of cytokinesis 10	2q36.3	1(0/0/1)
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)
TRIO	triple functional domain (PTPRF interacting)	5p14-p15.1	1(0/0/1)
SRGAP1	SLIT-ROBO Rho GTPase activating protein 1	12q13.13	1(0/0/1)
NET1	neuroepithelial cell transforming 1	10p15	0
DIRAS2	DIRAS family, GTP-binding RAS-like 2	9q22.32	1(1/0/0)

Genes from other sources (count: 51)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV
ARHGAP11A	Rho GTPase activating protein 11A	Mapped by CNV; Mapped by significant region
ARHGAP11B	Rho GTPase activating protein 11B	Mapped by significant region
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
RAB27A	RAB27A, member RAS oncogene family	Mapped by LD-proxy
PLD1	phospholipase D1, phosphatidylcholine-specific	Mapped by PBA pathway	TAS[8530346]
DOCK8	dedicator of cytokinesis 8	Mapped by CNV
RAB1B	RAB1B, member RAS oncogene family	Mapped by significant region
RHOD	ras homolog gene family, member D	Mapped by significant region
MCF2L	MCF.2 cell line derived transforming sequence-like	Mapped by CNV
ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	Mapped by significant region
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy
RAB2A	RAB2A, member RAS oncogene family	Mapped by PBA pathway
ARHGAP32	Rho GTPase activating protein 32	Mapped by significant region
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Mapped by significant region
ARHGAP19	Rho GTPase activating protein 19	Mapped by LD-proxy; Mapped by literature SNP
RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	Mapped by significant region	NAS[10486569]
ARHGAP20	Rho GTPase activating protein 20	Mapped by significant region
ARHGAP18	Rho GTPase activating protein 18	Mapped by CNV; Mapped by significant region
CHN2	chimerin (chimaerin) 2	Mapped by CNV
ARL17B	ADP-ribosylation factor-like 17B	Mapped by LD-proxy
RAB27B	RAB27B, member RAS oncogene family	Mapped by LD-proxy; Mapped by literature SNP
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	Mapped by CNV
ARF6	ADP-ribosylation factor 6	Mapped by PBA pathway
RGL1	ral guanine nucleotide dissociation stimulator-like 1	Mapped by significant region	NAS[10760592]
ARL2	ADP-ribosylation factor-like 2	Mapped by significant region
RAB38	RAB38, member RAS oncogene family	Mapped by significant region	NAS[10910072]
RASL11B	RAS-like, family 11, member B	Mapped by CNV
ARHGAP8	Rho GTPase activating protein 8	Mapped by CNV
RIT2	Ras-like without CAAX 2	Mapped by significant region	NAS[8824319]
RALGPS1	Ral GEF with PH domain and SH3 binding motif 1	Mapped by significant region
ARHGAP5	Rho GTPase activating protein 5	Mapped by significant region
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway
DIRAS1	DIRAS family, GTP-binding RAS-like 1	Mapped by LD-proxy
RAB30	RAB30, member RAS oncogene family	Mapped by significant region
FGD3	FYVE, RhoGEF and PH domain containing 3	Mapped by significant region
PLD2	phospholipase D2	Mapped by PBA pathway	TAS[9582313]
FAM13A	family with sequence similarity 13, member A	Mapped by CNV
IQGAP2	IQ motif containing GTPase activating protein 2	Mapped by CNV
RAB14	RAB14, member RAS oncogene family	Mapped by PBA pathway; Mapped by significant region
AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	Mapped by LD-proxy
RAB6C	RAB6C, member RAS oncogene family	Mapped by significant region	TAS[10455022]
ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	Mapped by significant region
RASGEF1C	RasGEF domain family, member 1C	Mapped by CNV
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region
RAB6A	RAB6A, member RAS oncogene family	Mapped by CNV; Mapped by significant region
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	Mapped by significant region
ARFIP2	ADP-ribosylation factor interacting protein 2	Mapped by CNV	TAS[8670882]
G3BP2	GTPase activating protein (SH3 domain) binding protein 2	Mapped by CNV
RGL4	ral guanine nucleotide dissociation stimulator-like 4	Mapped by CNV