ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DIRAS2
Symbol Alias	Di-Ras2, DKFZp761C07121
Approved Name	DIRAS family, GTP-binding RAS-like 2
Location	9q22.32
Position	chr9:93372114-93405386, -
External Links	HGNC: 19323 Entrez Gene: 54769 Ensembl: ENSG00000165023 UCSC: uc004aqx.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Reif, A., 2011	Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders.	Significant

Gene related SNPs (count: 25)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs16906711	Chr9:93373278(Fwd)	3_prime_UTR_variant	1(1/0/0)
rs689687	Chr9:93410201(Fwd)	upstream_gene_variant	1(0/1/0)
rs690111	Chr9:93377290(Fwd)	intron_variant	1(0/1/0)
rs1412005	Chr9:93409161(Fwd)	upstream_gene_variant	1(1/0/0)
rs1017753	Chr9:93377901(Fwd)	intron_variant	1(0/1/0)
rs7848810	Chr9:93407858(Fwd)	upstream_gene_variant	1(1/0/0)
rs7868194	Chr9:93369784(Fwd)	downstream_gene_variant	1(0/1/0)
rs7854469	Chr9:93372229(Fwd)	3_prime_UTR_variant	1(1/0/0)
rs2297354	Chr9:93404340(Fwd)	intron_variant	1(0/1/0)
rs1542479	Chr9:93373049(Fwd)	3_prime_UTR_variant	1(0/1/0)
rs1331503	Chr9:93402517(Fwd)	intron_variant	1(1/0/0)
rs1331504	Chr9:93405828(Fwd)	upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 4)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003924	GTPase activity	Molecular Function	41
GO:0005525	GTP binding	Molecular Function	53
GO:0005886	plasma membrane	Cellular Component	772
GO:0007264	small GTPase mediated signal transduction	Biological Process	58

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DIRAS2 (count: 0)

Genes shared at least 2 KEGG pathways with DIRAS2 (count: 0)

View in gBrowse

Region: chr9:93372114..93405386 View in gBrowse