ADHDgene Database

SNP Report

Basic Info

Name	rs1412005 dbSNP Ensembl
Location	chr9:93409161(Fwd)
Variant Alleles	T/G
Ancestral Allele	G
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000375765)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Reif, A., 2011	G/T		P-value=0.0182, OR (allele)=1.29 (T), 95% CI=1.04-1.58 in Ge...... P-value=0.0182, OR (allele)=1.29 (T), 95% CI=1.04-1.58 in German discovery sample; P-value=0.3785, OR (allele)=1.06 (T), 95% CI=0.93-1.21 in IMpACT replication sample; P-value=0.0437, OR (allele)=1.12 (T), 95% CI=1.00-1.25 in pooled data; PDT P-value=0.6565 for allele T in the family-based analysis More...	4 out of 12 investigated SNPs had p<0.05 in the association ...... 4 out of 12 investigated SNPs had p<0.05 in the association test with aADHD. Replication in 1035 aADHD patients and 1381 controls from IMpACT did not show any significant SNP association. The rs1412005 T allele was not significantly over-transmitted, but the C allele of the neighboring SNP rs7848810-also a promoter SNP-was. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DIRAS2	DIRAS family, GTP-binding RAS-like 2	9q22.32	1(1/0/0)

SNPs in LD with rs1412005 (count: 15) View in gBrowse (chr9:93402190..93436857 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs4744473	intron_variant	0.821[CHB]
rs7860740		1.0[CEU]; 1.0[TSI]; 0.882[ASW]; 1.0[CHB]; 0.9[CHD]; 0.952[JPT]; 0.947[GIH]; 0.956[LWK]; 0.956[MEX]; 0.929[YRI]
rs1017754	upstream_gene_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.811[GIH]; 0.801[MEX]; 0.833[YRI]
rs1360471		1.0[CEU]; 1.0[TSI]; 0.827[ASW]; 1.0[CHB]; 0.9[CHD]; 0.907[JPT]; 0.921[GIH]; 0.911[LWK]; 0.914[MEX]; 1.0[MKK]; 0.929[YRI]
rs12684237		1.0[CEU]; 1.0[TSI]; 1.0[CHB]; 0.975[CHD]; 1.0[JPT]; 0.973[GIH]; 0.914[MEX]
rs1831521	upstream_gene_variant	1.0[CEU]; 1.0[TSI]; 1.0[ASW]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 1.0[GIH]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[YRI]
rs7029114		0.809[CEU]
rs1331506		0.825[CEU]; 0.936[TSI]; 0.94[ASW]; 0.978[LWK]; 0.913[MEX]; 0.986[MKK]; 0.964[YRI]
rs6479615		0.809[CEU]; 0.934[TSI]; 0.866[GIH]
rs1331502	intron_variant	0.955[CHB]; 0.953[JPT]
rs7854744	upstream_gene_variant	0.955[CHB]; 0.952[JPT]
rs6479614		1.0[CEU]; 1.0[CHB]; 0.952[JPT]; 0.929[YRI]
rs1466381	intron_variant	0.809[CEU]; 0.869[TSI]; 0.92[GIH]
rs1331494		0.809[CEU]
rs1819453		0.809[CEU]; 0.934[TSI]; 0.866[GIH]