ADHDgene Database

SNP Report

Basic Info

Name	rs2297354 dbSNP Ensembl
Location	Chr9:93404340(Fwd)
Variant Alleles	G/C
Ancestral Allele	G
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000375765)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Reif, A., 2011	C/G		P-value=0.2101, OR (allele)=1.62 (G), 95% CI=0.76-3.44 in Ge...... P-value=0.2101, OR (allele)=1.62 (G), 95% CI=0.76-3.44 in German discovery sample; P-value=0.6599, OR (allele)=1.11 (G), 95% CI=0.70-1.77 in IMpACT replication sample; P-value=0.288, OR (allele)=1.24 (G) , 95% CI=0.84-1.82 in pooled data; PDT P-value=0.2253 for allele C in the family-based analysis More...	This SNP did not reach p<0.05 in the association test with a...... This SNP did not reach p<0.05 in the association test with aADHD. Replication in 1035 aADHD patients and 1381 controls from IMpACT did not show any significant SNP association. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DIRAS2	DIRAS family, GTP-binding RAS-like 2	9q22.32	1(1/0/0)

SNPs in LD with rs2297354 (count: 3) View in gBrowse (chr9:93373049..93404408 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs1542479	3_prime_UTR_variant	1(0/1/0)	0.877[CHB]; 0.897[JPT]

rs_ID	Functional Annotation	r²[population]
rs2297353	intron_variant	1.0[CHB]; 1.0[JPT]
rs16906728	intron_variant	0.877[CHB]; 0.897[JPT]