ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ARHGAP8
Symbol Alias	FLJ20185, BPGAP1
Approved Name	Rho GTPase activating protein 8
Location	22q13.3
Position	chr22:45098355-45258665, 1
External Links	HGNC: 677 Entrez Gene: 23779 Ensembl: ENSG00000241484
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_217	chr22:43547810-43578994 (NCBI Build 35 (hg17))	31185	22q13.31	Deletion (hemizygous)	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	32
GO:0032321	positive regulation of Rho GTPase activity	biological process	IDA	6
GO:0070374	positive regulation of ERK1 and ERK2 cascade	biological process	IDA	23
GO:0005829	cytosol	cellular component	TAS	485
GO:0005515	protein binding	molecular function	IPI	1015
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	65
GO:0005100	Rho GTPase activator activity	molecular function	IDA	6

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ARHGAP8 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ARHGAP5	5	regulation of small GTPase mediated signal transduction; positive regulation of Rho GTPase activity; cytosol; small GTPase mediated signal transduction; Rho GTPase activator activity;
ARAP1	5	regulation of small GTPase mediated signal transduction; cytosol; protein binding; small GTPase mediated signal transduction; Rho GTPase activator activity;

Genes shared at least 2 KEGG pathways with ARHGAP8 (count: 0)

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Region: chr22:45098355..45258665 View in gBrowse