ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004871
Name	signal transducer activity
Type	Molecular Function
No. of Genes in ADHDgene	49
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 49)

Literature-origin genes (count: 11)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	1(1/0/0)
PER2	period homolog 2 (Drosophila)	2q37.3	1(1/0/0)
PER1	period homolog 1 (Drosophila)	17p13.1	1(0/1/0)
TSPAN8	tetraspanin 8	12q14.1-q21.1	1(0/1/0)	TAS[2395876]
PLCL1	phospholipase C-like 1	2q33	1(0/0/1)
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	1p13	1(1/0/0)
GNAZ	guanine nucleotide binding protein (G protein), alpha z polypeptide	22q11.1-q11.2	1(0/1/0)
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	7q21	1(0/0/1)
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	16q13	1(0/1/0)
NPAS3	neuronal PAS domain protein 3	14q12-q13	1(1/0/0)

Genes from other sources (count: 38)

Approved Symbol	Approved Name	Source	Evidence[PMID]
PLCB2	phospholipase C, beta 2	Mapped by PBA pathway
GJA1	gap junction protein, alpha 1, 43kDa	Mapped by significant region	IMP[12761501]
PLCXD3	phosphatidylinositol-specific phospholipase C, X domain containing 3	Mapped by significant region
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	Mapped by significant region	TAS[8808684]
IL10RA	interleukin 10 receptor, alpha	Mapped by significant region	TAS[8120391]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IMP[12761501]
APOL3	apolipoprotein L, 3	Mapped by CNV	IMP[12761501]
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Mapped by significant region
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	Mapped by significant region
BCAR1	breast cancer anti-estrogen resistance 1	Mapped by significant region	TAS[8070403]
GNG10	guanine nucleotide binding protein (G protein), gamma 10	Mapped by significant region
SH2B3	SH2B adaptor protein 3	Mapped by LD-proxy
STMN1	stathmin 1	Mapped by PBA pathway	TAS[8003023]
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	Mapped by significant region	TAS[7796809]
CXCR2	chemokine (C-X-C motif) receptor 2	Mapped by significant region	IDA[10878382]
IL11RA	interleukin 11 receptor, alpha	Mapped by LD-proxy	TAS[8786120]
PLCH1	phospholipase C, eta 1	Mapped by PBA pathway
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Mapped by significant region
AIP	aryl hydrocarbon receptor interacting protein	Mapped by significant region	TAS[9111057]
ZP4	zona pellucida glycoprotein 4	Mapped by CNV	IMP[18667750]
DIXDC1	DIX domain containing 1	Mapped by significant region
CHKA	choline kinase alpha	Mapped by significant region	TAS[10363580]
FAM126A	family with sequence similarity 126, member A	Mapped by significant region	NAS[10910037]
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	Mapped by CNV	TAS[8798523]
TRIM13	tripartite motif containing 13	Mapped by LD-proxy	IMP[12761501]
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	Mapped by significant region
ILK	integrin-linked kinase	Mapped by CNV
PLCD1	phospholipase C, delta 1	Mapped by PBA pathway
IKBKAP	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	Mapped by significant region	TAS[9751059]
OMP	olfactory marker protein	Mapped by significant region
PLCD4	phospholipase C, delta 4	Mapped by significant region
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region	IMP[12761501]
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	Mapped by LD-proxy; Mapped by literature SNP	IMP[12761501]
NPAS2	neuronal PAS domain protein 2	Mapped by CNV
PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1	Mapped by CNV; Mapped by significant region	TAS[10585447]
NPAS4	neuronal PAS domain protein 4	Mapped by significant region
CLTCL1	clathrin, heavy chain-like 1	Mapped by CNV	TAS[8844170]