ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004871
Name signal transducer activity
Type molecular function
No. of Genes in ADHDgene  56
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 56)

Literature-origin genes (count: 12)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
PLCL1 phospholipase C-like 1 2q33 1(0/0/1) IEA
CLOCK clock circadian regulator 4q12 2(2/0/0) IEA
TSPAN8 tetraspanin 8 12q14.1-q21.1 1(0/1/0) TAS[2395876]
SH2B1 SH2B adaptor protein 1 16p11.2 1(0/1/0) IEA
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0) IBA
NPAS3 neuronal PAS domain protein 3 14q13.1 1(1/0/0) IEA
PER1 period circadian clock 1 17p13.1 1(0/1/0) IEA
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 1p13 1(1/0/0) IBA
PER2 period circadian clock 2 2q37.3 1(1/0/0) IEA
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 22q11.1-q11.2 1(0/1/0) IBA
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 7q21 1(0/0/1) IEA
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0) IBA

Genes from other sources Help (count: 44)

Approved Symbol Approved Name Source Evidence[PMID]
PLCB2 phospholipase C, beta 2 Mapped by PBA pathway IEA
AHRR aryl-hydrocarbon receptor repressor Mapped by significant region IEA
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase Mapped by significant region IEA
APOL3 apolipoprotein L, 3 Mapped by CNV IMP[12761501]
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like Mapped by CNV TAS[8798523]
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) Mapped by significant region IEA
PLCD4 phospholipase C, delta 4 Mapped by significant region IEA
OMP olfactory marker protein Mapped by significant region IEA
PLCD1 phospholipase C, delta 1 Mapped by PBA pathway IEA
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 Mapped by significant region TAS[8808684]
AXIN1 axin 1 Mapped by significant region IDA[9601641]
STMN1 stathmin 1 Mapped by PBA pathway TAS[8003023]
GNG13 guanine nucleotide binding protein (G protein), gamma 13 Mapped by significant region IEA
CHKA choline kinase alpha Mapped by significant region TAS[10363580]
FAM126A family with sequence similarity 126, member A Mapped by significant region NAS[10910037]
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein Mapped by significant region TAS[9751059]
LITAF lipopolysaccharide-induced TNF factor Mapped by significant region IMP[12761501]
MAVS mitochondrial antiviral signaling protein Mapped by CNV IMP
SH2B3 SH2B adaptor protein 3 Mapped by LD-proxy IEA
GJA1 gap junction protein, alpha 1, 43kDa Mapped by Literature SNP; Mapped by significant region IMP[12761501]
DIXDC1 DIX domain containing 1 Mapped by significant region IEA
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region IMP[12761501]
ILK integrin-linked kinase Mapped by CNV IEA
PLCH1 phospholipase C, eta 1 Mapped by PBA pathway IEA
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) Mapped by significant region IEA
BCAR1 breast cancer anti-estrogen resistance 1 Mapped by significant region TAS[8070403]
TRIM13 tripartite motif containing 13 Mapped by LD-proxy IMP[12761501]
ZP4 zona pellucida glycoprotein 4 Mapped by CNV IMP[18667750]
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 Mapped by significant region TAS[7796809]
NPAS4 neuronal PAS domain protein 4 Mapped by significant region IEA
AIP aryl hydrocarbon receptor interacting protein Mapped by significant region TAS[9111057]
IL11RA interleukin 11 receptor, alpha Mapped by LD-proxy TAS[8786120]
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region IEA
IL10RA interleukin 10 receptor, alpha Mapped by significant region TAS[8120391]
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) Mapped by Literature SNP IMP[12761501]
CLTCL1 clathrin, heavy chain-like 1 Mapped by CNV TAS[8844170]
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region IEA
CXCR2 chemokine (C-X-C motif) receptor 2 Mapped by significant region IDA[10878382]
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 Mapped by significant region IEA
NEK6 NIMA-related kinase 6 Mapped by significant region IMP[12761501]
CREBBP CREB binding protein Mapped by significant region TAS[8028671]
RGS11 regulator of G-protein signaling 11 Mapped by significant region IEA
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1 Mapped by CNV; Mapped by significant region TAS[10585447]
NPAS2 neuronal PAS domain protein 2 Mapped by CNV IEA