ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0019901
Name	protein kinase binding
Type	Molecular Function
No. of Genes in ADHDgene	51
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 51)

Literature-origin genes (count: 6)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IPI[18348280]
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	IPI[15653687]
PRKAG2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	7q35-q36	1(0/0/1)	IDA[10698692]
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	IPI[11279118]
PTPRJ	protein tyrosine phosphatase, receptor type, J	11p11.2	1(0/1/0)	IPI[19332538]
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	6q25.2-q27	1(1/0/0)

Genes from other sources (count: 45)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CNPPD1	cyclin Pas1/PHO80 domain containing 1	Mapped by significant region
MAVS	mitochondrial antiviral signaling protein	Mapped by CNV	IPI[16127453]
SYK	spleen tyrosine kinase	Mapped by significant region
PLK1	polo-like kinase 1	Mapped by significant region
BAD	BCL2-associated agonist of cell death	Mapped by significant region	IPI[17270021]
ILK	integrin-linked kinase	Mapped by CNV	IPI[19118217]
RPTOR	regulatory associated protein of MTOR, complex 1	Mapped by LD-proxy	IPI[18439900]
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IPI[15899872]
USP37	ubiquitin specific peptidase 37	Mapped by significant region
CEP250	centrosomal protein 250kDa	Mapped by PBA pathway	IPI[9647649]
SPDYC	speedy homolog C (Xenopus laevis)	Mapped by significant region	IPI[15611625]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region
CDC25B	cell division cycle 25 homolog B (S. pombe)	Mapped by CNV	IPI[15908796]
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region
MAML1	mastermind-like 1 (Drosophila)	Mapped by CNV	IPI[15546612]
GATA6	GATA binding protein 6	Mapped by significant region
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	Mapped by PBA pathway; Mapped by significant region
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway	IPI[8638126]
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	Mapped by PBA pathway	IPI[19927127]
BCAR1	breast cancer anti-estrogen resistance 1	Mapped by significant region	IPI[10026197]
STK11IP	serine/threonine kinase 11 interacting protein	Mapped by significant region	IPI[11741830]
KIF11	kinesin family member 11	Mapped by PBA pathway	IPI[19001501]
PRKAG3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	Mapped by significant region	IDA[10698692]
CENPJ	centromere protein J	Mapped by PBA pathway
LLGL1	lethal giant larvae homolog 1 (Drosophila)	Mapped by significant region	IDA[7542763]
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region	IPI[19001501]
RAD9A	RAD9 homolog A (S. pombe)	Mapped by significant region	IPI[12628935]
SQSTM1	sequestosome 1	Mapped by CNV	IDA[8650207]
LIPE	lipase, hormone-sensitive	Mapped by PBA pathway
PRC1	protein regulator of cytokinesis 1	Mapped by PBA pathway	IPI[17351640]
PPME1	protein phosphatase methylesterase 1	Mapped by PBA pathway; Mapped by significant region
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	Mapped by significant region	NAS[12110186]
TPCN2	two pore segment channel 2	Mapped by CNV; Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IPI[15465828]
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IPI[10721722]
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mapped by LD-proxy; Mapped by significant region
MAPT	microtubule-associated protein tau	Mapped by LD-proxy; Mapped by PBA pathway
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region
RPS3	ribosomal protein S3	Mapped by significant region	IPI[15950189]
THY1	Thy-1 cell surface antigen	Mapped by significant region
AKAP7	A kinase (PRKA) anchor protein 7	Mapped by significant region
DAB2IP	DAB2 interacting protein	Mapped by significant region
CCND1	cyclin D1	Mapped by significant region	IPI[8114739]
RNF138	ring finger protein 138	Mapped by significant region	IPI[16714285]