ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0005543
Name	phospholipid binding
Type	Molecular Function
No. of Genes in ADHDgene	61
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 61)

Literature-origin genes (count: 12)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
PLCL1	phospholipase C-like 1	2q33	1(0/0/1)
TIAM2	T-cell lymphoma invasion and metastasis 2	6q25	1(0/0/1)
DOCK10	dedicator of cytokinesis 10	2q36.3	1(0/0/1)
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)
NET1	neuroepithelial cell transforming 1	10p15	0
TRIO	triple functional domain (PTPRF interacting)	5p14-p15.1	1(0/0/1)
PHLDA1	pleckstrin homology-like domain, family A, member 1	12q15	1(0/1/0)
ADRBK1	adrenergic, beta, receptor kinase 1	11q13	1(0/1/0)
DGKH	diacylglycerol kinase, eta	13q13.3	1(1/0/0)
ADRBK2	adrenergic, beta, receptor kinase 2	22q11	1(0/1/0)
SYT1	synaptotagmin I	12cen-q21	4(2/2/0)	TAS[1840599]
DNM1	dynamin 1	9q34	1(0/0/1)

Genes from other sources (count: 49)

Approved Symbol	Approved Name	Source	Evidence[PMID]
SNTG2	syntrophin, gamma 2	Mapped by CNV
SPATA13	spermatogenesis associated 13	Mapped by CNV
FERMT3	fermitin family member 3	Mapped by significant region
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	Mapped by significant region
NR5A1	nuclear receptor subfamily 5, group A, member 1	Mapped by significant region	IDA[17664281]
PRKD1	protein kinase D1	Mapped by significant region
RASA1	RAS p21 protein activator (GTPase activating protein) 1	Mapped by PBA pathway
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region
DOK6	docking protein 6	Mapped by CNV
APOA1	apolipoprotein A-I	Mapped by significant region	IDA[12810715]
STAP1	signal transducing adaptor family member 1	Mapped by significant region
BAD	BCL2-associated agonist of cell death	Mapped by significant region
GRB10	growth factor receptor-bound protein 10	Mapped by LD-proxy
APOA5	apolipoprotein A-V	Mapped by significant region	IDA[12810715]
SYNGAP1	synaptic Ras GTPase activating protein 1	Mapped by LD-proxy; Mapped by literature SNP
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region
ARHGAP42	Rho GTPase activating protein 42	Mapped by significant region
SPTBN2	spectrin, beta, non-erythrocytic 2	Mapped by significant region
SH2B3	SH2B adaptor protein 3	Mapped by LD-proxy
ARHGAP20	Rho GTPase activating protein 20	Mapped by significant region
PLCH1	phospholipase C, eta 1	Mapped by PBA pathway
MPRIP	myosin phosphatase Rho interacting protein	Mapped by significant region
APOC3	apolipoprotein C-III	Mapped by significant region	IDA[11060345]
OSBPL3	oxysterol binding protein-like 3	Mapped by CNV; Mapped by significant region
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	Mapped by PBA pathway	IDA[9032461]
PHLDB1	pleckstrin homology-like domain, family B, member 1	Mapped by significant region
F10	coagulation factor X	Mapped by CNV	IDA[17469850]
OSBP	oxysterol binding protein	Mapped by significant region
FGD3	FYVE, RhoGEF and PH domain containing 3	Mapped by significant region
OSBPL1A	oxysterol binding protein-like 1A	Mapped by significant region	NAS[11279184]
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	Mapped by significant region
SKAP2	src kinase associated phosphoprotein 2	Mapped by significant region
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	Mapped by CNV; Mapped by significant region	IC[16702602]
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
PLCD1	phospholipase C, delta 1	Mapped by PBA pathway
AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	Mapped by LD-proxy
LPAR1	lysophosphatidic acid receptor 1	Mapped by significant region
PLEKHB2	pleckstrin homology domain containing, family B (evectins) member 2	Mapped by CNV; Mapped by significant region
PLEKHH2	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	Mapped by CNV
DAB2IP	DAB2 interacting protein	Mapped by significant region
RALGPS1	Ral GEF with PH domain and SH3 binding motif 1	Mapped by significant region
PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1	Mapped by CNV; Mapped by significant region
PLCD4	phospholipase C, delta 4	Mapped by significant region
PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)	Mapped by PBA pathway	NAS[10085124]
FAM129B	family with sequence similarity 129, member B	Mapped by significant region
ASAP2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	Mapped by significant region
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	Mapped by significant region
TBC1D2	TBC1 domain family, member 2	Mapped by significant region
ITK	IL2-inducible T-cell kinase	Mapped by significant region