ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0007399
Name	nervous system development
Type	Biological Process
No. of Genes in ADHDgene	54
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 54)

Literature-origin genes (count: 16)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GRIK1	glutamate receptor, ionotropic, kainate 1	21q22	1(0/0/1)	TAS[8260617]
CHRNA3	cholinergic receptor, nicotinic, alpha 3	15q24	1(0/1/0)	IMP[11450844]
NTF3	neurotrophin 3	12p13	3(1/2/0)	TAS[1542658]
HES6	hairy and enhancer of split 6 (Drosophila)	2q37.3	1(0/1/0)
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)	TAS[10036192]
MYT1L	myelin transcription factor 1-like	2p25.3	1(0/0/1)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)	TAS[8020957]
NRSN1	neurensin 1	6p22.1	1(1/0/0)
CNTFR	ciliary neurotrophic factor receptor	9p13	1(1/0/0)	TAS[7585948]
CPLX2	complexin 2	5q35.2	2(1/0/1)
CNTN4	contactin 4	3p26.3	1(1/0/0)	IMP[15106122]
ZNF423	zinc finger protein 423	16q12	1(0/0/1)
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	TAS[8637574]
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	TAS[15351965]
BDNF	brain-derived neurotrophic factor	11p14.1	14(8/6/0)	TAS[2236018]
MOBP	myelin-associated oligodendrocyte basic protein	3p21.33	1(0/0/1)

Genes from other sources (count: 38)

Approved Symbol	Approved Name	Source	Evidence[PMID]
CTF1	cardiotrophin 1	Mapped by CNV	TAS[7738033]
AQP4	aquaporin 4	Mapped by significant region	TAS[7528931]
NBL1	neuroblastoma, suppression of tumorigenicity 1	Mapped by LD-proxy
FABP7	fatty acid binding protein 7, brain	Mapped by significant region	TAS[9375786]
NINJ1	ninjurin 1	Mapped by significant region	TAS[9261151]
CABLES1	Cdk5 and Abl enzyme substrate 1	Mapped by significant region
DOC2A	double C2-like domains, alpha	Mapped by CNV	TAS[7826360]
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	ISS[16297881]
TRIM3	tripartite motif containing 3	Mapped by CNV	TAS[10391919]
TPP1	tripeptidyl peptidase I	Mapped by CNV	IMP[9295267]
LHX1	LIM homeobox 1	Mapped by CNV	TAS[9212161]
NEUROD2	neurogenic differentiation 2	Mapped by LD-proxy	TAS[8816493]
INHA	inhibin, alpha	Mapped by significant region	NAS[10320815]
MARK4	MAP/microtubule affinity-regulating kinase 4	Mapped by PBA pathway	IDA[14594945]
NLGN1	neuroligin 1	Mapped by CNV
SLC7A5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mapped by significant region
APBA2	amyloid beta (A4) precursor protein-binding, family A, member 2	Mapped by CNV; Mapped by significant region	TAS[9890987]
RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5	Mapped by significant region	NAS[10486569]
NDN	necdin homolog (mouse)	Mapped by CNV; Mapped by significant region	TAS[9630521]
SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Mapped by CNV
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	Mapped by CNV; Mapped by PBA pathway	TAS[7670466]
GAL	galanin prepropeptide	Mapped by CNV; Mapped by significant region
AHNAK	AHNAK nucleoprotein	Mapped by significant region
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy	TAS[15504738]
SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	Mapped by significant region	TAS[9635427]
FEZ1	fasciculation and elongation protein zeta 1 (zygin I)	Mapped by significant region	TAS[9096408]
DGCR14	DiGeorge syndrome critical region gene 14	Mapped by CNV	ISS[8703114]
NRGN	neurogranin (protein kinase C substrate, RC3)	Mapped by significant region	TAS[10075657]
TRPC5	transient receptor potential cation channel, subfamily C, member 5	Mapped by PBA pathway	TAS[10493832]
CHRM1	cholinergic receptor, muscarinic 1	Mapped by PBA pathway; Mapped by significant region	TAS[2739737]
SDCBP2	syndecan binding protein (syntenin) 2	Mapped by LD-proxy; Mapped by literature SNP	NAS[11152476]
ACHE	acetylcholinesterase	Mapped by PBA pathway	TAS[11283752]
SIGMAR1	sigma non-opioid intracellular receptor 1	Mapped by LD-proxy
FKTN	fukutin	Mapped by significant region	TAS[9690476]
SCN2B	sodium channel, voltage-gated, type II, beta	Mapped by significant region
CHRM3	cholinergic receptor, muscarinic 3	Mapped by CNV; Mapped by PBA pathway	TAS[2739737]
FGF19	fibroblast growth factor 19	Mapped by significant region	TAS[9931477]
DPYSL4	dihydropyrimidinase-like 4	Mapped by CNV	TAS[9652388]