ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0019221
Name cytokine-mediated signaling pathway
Type biological process
No. of Genes in ADHDgene  33
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 33)

Literature-origin genes (count: 2)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 6p21.3 2(1/1/0) TAS
EREG epiregulin 4q21.21 1(0/0/1) IDA[9419975]

Genes from other sources Help (count: 31)

Approved Symbol Approved Name Source Evidence[PMID]
CLCF1 cardiotrophin-like cytokine factor 1 Mapped by significant region NAS[10500198]
NUP155 nucleoporin 155kDa Mapped by significant region TAS
NCAM1 neural cell adhesion molecule 1 Mapped by significant region TAS
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 Mapped by CNV TAS
IRF8 interferon regulatory factor 8 Mapped by significant region TAS
CAMK2D calcium/calmodulin-dependent protein kinase II delta Mapped by CNV TAS
DUOX1 dual oxidase 1 Mapped by CNV IDA[16111680]
SOCS1 suppressor of cytokine signaling 1 Mapped by significant region ISS; TAS
NUP160 nucleoporin 160kDa Mapped by LD-proxy TAS
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
PTPRN protein tyrosine phosphatase, receptor type, N Mapped by significant region IEA
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IDA[15876188]
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IDA[2261637]
IFNGR1 interferon gamma receptor 1 Mapped by significant region TAS
DUOX2 dual oxidase 2 Mapped by CNV IDA[16111680]; ISS
UBC ubiquitin C Mapped by CNV TAS
UBB ubiquitin B Mapped by significant region TAS
UBE2L6 ubiquitin-conjugating enzyme E2L 6 Mapped by significant region TAS
IRF9 interferon regulatory factor 9 Mapped by significant region TAS
LIFR leukemia inhibitory factor receptor alpha Mapped by significant region IDA[7957045]
RQCD1 RCD1 required for cell differentiation1 homolog (S. pombe) Mapped by significant region IEA
BAD BCL2-associated agonist of cell death Mapped by significant region IEA
KPNA5 karyopherin alpha 5 (importin alpha 6) Mapped by CNV; Mapped by significant region TAS
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region TAS
CIITA class II, major histocompatibility complex, transactivator Mapped by significant region TAS
IRF7 interferon regulatory factor 7 Mapped by LD-proxy TAS
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 Mapped by CNV TAS
NUPL2 nucleoporin like 2 Mapped by CNV; Mapped by significant region TAS
OASL 2'-5'-oligoadenylate synthetase-like Mapped by PBA pathway TAS
NUP62 nucleoporin 62kDa Mapped by PBA pathway TAS
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 Mapped by CNV TAS