ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0019221
Name	cytokine-mediated signaling pathway
Type	Biological Process
No. of Genes in ADHDgene	28
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 28)

Literature-origin genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
EREG	epiregulin	4q21.21	1(0/0/1)	IDA[9419975]
HLA-DRB1	major histocompatibility complex, class II, DR beta 1	6p21.3	2(1/1/0)

Genes from other sources (count: 26)

Approved Symbol	Approved Name	Source	Evidence[PMID]
BAD	BCL2-associated agonist of cell death	Mapped by significant region
IRF8	interferon regulatory factor 8	Mapped by significant region
IL6	interleukin 6 (interferon, beta 2)	Mapped by significant region	IDA[2261637]
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV
UBE2L6	ubiquitin-conjugating enzyme E2L 6	Mapped by significant region
CAMK2D	calcium/calmodulin-dependent protein kinase II delta	Mapped by CNV
RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	Mapped by significant region
KPNA5	karyopherin alpha 5 (importin alpha 6)	Mapped by CNV; Mapped by significant region
IRF9	interferon regulatory factor 9	Mapped by significant region
NUP62	nucleoporin 62kDa	Mapped by PBA pathway
PTPRN	protein tyrosine phosphatase, receptor type, N	Mapped by significant region
HERC5	hect domain and RLD 5	Mapped by CNV
CLCF1	cardiotrophin-like cytokine factor 1	Mapped by significant region	NAS[10500198]
DUOX2	dual oxidase 2	Mapped by CNV	IDA[16111680]
IRF7	interferon regulatory factor 7	Mapped by LD-proxy
UBB	ubiquitin B	Mapped by significant region
RQCD1	RCD1 required for cell differentiation1 homolog (S. pombe)	Mapped by significant region
UBC	ubiquitin C	Mapped by CNV
LIFR	leukemia inhibitory factor receptor alpha	Mapped by significant region	IDA[7957045]
DUOX1	dual oxidase 1	Mapped by CNV	IDA[16111680]
IFNGR1	interferon gamma receptor 1	Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[15876188]
NCAM1	neural cell adhesion molecule 1	Mapped by significant region
NUPL2	nucleoporin like 2	Mapped by CNV; Mapped by significant region
NUP155	nucleoporin 155kDa	Mapped by significant region
OASL	2'-5'-oligoadenylate synthetase-like	Mapped by PBA pathway