ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004222
Name	metalloendopeptidase activity
Type	Molecular Function
No. of Genes in ADHDgene	33
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 33)

Literature-origin genes (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
NLN	neurolysin (metallopeptidase M3 family)	5q12.3	1(1/0/0)
TLL2	tolloid-like 2	10q23-q24	1(0/0/1)
MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11q21-q22	1(0/0/1)
MMP24	matrix metallopeptidase 24 (membrane-inserted)	20q11.2	1(0/0/1)

Genes from other sources (count: 29)

Approved Symbol	Approved Name	Source	Evidence[PMID]
SPG7	spastic paraplegia 7 (pure and complicated autosomal recessive)	Mapped by significant region	IDA[11549317]
ADAMTS7	ADAM metallopeptidase with thrombospondin type 1 motif, 7	Mapped by LD-proxy
ADAMTS8	ADAM metallopeptidase with thrombospondin type 1 motif, 8	Mapped by significant region
MMP12	matrix metallopeptidase 12 (macrophage elastase)	Mapped by significant region	TAS[8226919]
ADAM8	ADAM metallopeptidase domain 8	Mapped by CNV; Mapped by LD-proxy
MMP11	matrix metallopeptidase 11 (stromelysin 3)	Mapped by CNV
C9orf3	chromosome 9 open reading frame 3	Mapped by significant region
TRHDE	thyrotropin-releasing hormone degrading enzyme	Mapped by LD-proxy
ASTL	astacin-like metallo-endopeptidase (M12 family)	Mapped by LD-proxy	IDA[15087446]
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	Mapped by significant region
UQCRC2	ubiquinol-cytochrome c reductase core protein II	Mapped by CNV; Mapped by significant region
TLL1	tolloid-like 1	Mapped by LD-proxy; Mapped by literature SNP
MMP13	matrix metallopeptidase 13 (collagenase 3)	Mapped by significant region
RCE1	RCE1 homolog, prenyl protein peptidase (S. cerevisiae)	Mapped by significant region	TAS[10085068]
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	Mapped by significant region	IDA[9920899]
THOP1	thimet oligopeptidase 1	Mapped by LD-proxy
ADAMTS12	ADAM metallopeptidase with thrombospondin type 1 motif, 12	Mapped by significant region
MMP16	matrix metallopeptidase 16 (membrane-inserted)	Mapped by CNV
ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif, 15	Mapped by significant region
ADAMTS18	ADAM metallopeptidase with thrombospondin type 1 motif, 18	Mapped by CNV; Mapped by significant region
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	Mapped by CNV; Mapped by literature SNP
MMP27	matrix metallopeptidase 27	Mapped by significant region
MMP10	matrix metallopeptidase 10 (stromelysin 2)	Mapped by significant region
ADAM19	ADAM metallopeptidase domain 19	Mapped by significant region
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	Mapped by significant region
MMP20	matrix metallopeptidase 20	Mapped by significant region
MEP1B	meprin A, beta	Mapped by significant region
ADAM33	ADAM metallopeptidase domain 33	Mapped by CNV	NAS[11814695]
ADAM17	ADAM metallopeptidase domain 17	Mapped by significant region	IDA[9920899]; IMP[9034191]