ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0003924
Name	GTPase activity
Type	Molecular Function
No. of Genes in ADHDgene	41
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 41)

Literature-origin genes (count: 6)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	1(1/0/0)	TAS[8243272]
GNAZ	guanine nucleotide binding protein (G protein), alpha z polypeptide	22q11.1-q11.2	1(0/1/0)
DIRAS2	DIRAS family, GTP-binding RAS-like 2	9q22.32	1(1/0/0)
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	16q13	1(0/1/0)
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	1p13	1(1/0/0)
DNM1	dynamin 1	9q34	1(0/0/1)

Genes from other sources (count: 35)

Approved Symbol	Approved Name	Source	Evidence[PMID]
RIT2	Ras-like without CAAX 2	Mapped by significant region	NAS[8824319]
HBS1L	HBS1-like (S. cerevisiae)	Mapped by significant region
RAB27A	RAB27A, member RAS oncogene family	Mapped by LD-proxy
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway	TAS[10400640]
EHD3	EH-domain containing 3	Mapped by CNV
TUBG1	tubulin, gamma 1	Mapped by PBA pathway
RAB6A	RAB6A, member RAS oncogene family	Mapped by CNV; Mapped by significant region	IDA[18243103]
EFTUD2	elongation factor Tu GTP binding domain containing 2	Mapped by PBA pathway
RAB30	RAB30, member RAS oncogene family	Mapped by significant region	TAS[9792283]
TUBA3E	tubulin, alpha 3e	Mapped by significant region
DIRAS1	DIRAS family, GTP-binding RAS-like 1	Mapped by LD-proxy
RHOD	ras homolog gene family, member D	Mapped by significant region	TAS[9116026]
EHD1	EH-domain containing 1	Mapped by significant region
ARHGAP5	Rho GTPase activating protein 5	Mapped by significant region	TAS[8537347]
ARF6	ADP-ribosylation factor 6	Mapped by PBA pathway	TAS[1993656]
TUBA3D	tubulin, alpha 3d	Mapped by CNV; Mapped by significant region
RAB38	RAB38, member RAS oncogene family	Mapped by significant region	NAS[10910072]
RNF112	ring finger protein 112	Mapped by significant region
TUBA4A	tubulin, alpha 4a	Mapped by significant region
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region
GNG10	guanine nucleotide binding protein (G protein), gamma 10	Mapped by significant region	TAS[7665596]
AGAP3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	Mapped by LD-proxy
RAB2A	RAB2A, member RAS oncogene family	Mapped by PBA pathway	IDA[16034420]
TUBB3	tubulin, beta 3	Mapped by significant region
RAB14	RAB14, member RAS oncogene family	Mapped by PBA pathway; Mapped by significant region	IDA[16034420]; NAS[15004230]
SEPT5	septin 5	Mapped by CNV	TAS[9385360]
MTG1	mitochondrial GTPase 1 homolog (S. cerevisiae)	Mapped by CNV
ATL3	atlastin GTPase 3	Mapped by significant region	NAS[18270207]
RASL11B	RAS-like, family 11, member B	Mapped by CNV
ARL2	ADP-ribosylation factor-like 2	Mapped by significant region	IMP[10831612]
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Mapped by significant region	TAS[10075696]
OPA1	optic atrophy 1 (autosomal dominant)	Mapped by CNV	TAS[11017080]
RAB27B	RAB27B, member RAS oncogene family	Mapped by LD-proxy; Mapped by literature SNP
SRPR	signal recognition particle receptor (docking protein)	Mapped by significant region
RAB6C	RAB6C, member RAS oncogene family	Mapped by significant region	IDA[10455022]