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- Data Summary
GO Report
Basic Info
| ID | GO:0007626 |
|---|---|
| Name | locomotory behavior |
| Type | Biological Process |
| No. of Genes in ADHDgene | 24 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 24)
Literature-origin genes (count: 14)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | 9q34 | 20(11/9/0) | |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 16q13 | 1(0/1/0) | |
| SLC18A2 | solute carrier family 18 (vesicular monoamine), member 2 | 10q25 | 2(0/2/0) | |
| GRM5 | glutamate receptor, metabotropic 5 | 11q14.3 | 2(1/0/1) | |
| TH | tyrosine hydroxylase | 11p15.5 | 7(2/5/0) | |
| DRD3 | dopamine receptor D3 | 3q13.3 | 8(1/7/0) | |
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 5p15.3 | 68(42/25/1) | |
| OPRM1 | opioid receptor, mu 1 | 6q24-q25 | 1(1/0/0) | |
| GRM1 | glutamate receptor, metabotropic 1 | 6q24 | 1(1/0/0) | |
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 | 20 | 7(4/3/0) | |
| DRD2 | dopamine receptor D2 | 11q22-q23 | 10(3/7/0) | |
| ADRA1B | adrenergic, alpha-1B-, receptor | 5q33.3 | 2(1/1/0) | |
| CHRNA3 | cholinergic receptor, nicotinic, alpha 3 | 15q24 | 1(0/1/0) | |
| NPAS3 | neuronal PAS domain protein 3 | 14q12-q13 | 1(1/0/0) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| BSX | brain-specific homeobox | Mapped by significant region | |
| ADORA2A | adenosine A2a receptor | Mapped by CNV | |
| CACNA1E | calcium channel, voltage-dependent, R type, alpha 1E subunit | Mapped by PBA pathway; Mapped by significant region | |
| GRM6 | glutamate receptor, metabotropic 6 | Mapped by CNV | |
| SEPP1 | selenoprotein P, plasma, 1 | Mapped by CNV | |
| APBA2 | amyloid beta (A4) precursor protein-binding, family A, member 2 | Mapped by CNV; Mapped by significant region | |
| NOVA1 | neuro-oncological ventral antigen 1 | Mapped by significant region | TAS[8558240] |
| MYO15A | myosin XVA | Mapped by significant region | |
| CHRNB4 | cholinergic receptor, nicotinic, beta 4 | Mapped by LD-proxy | |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | Mapped by significant region |