ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04510
Name Focal adhesion
Description  Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
No. of Genes in ADHDgene  40
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 40)

Literature-origin genes (count: 5)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
FLNC filamin C, gamma 7q32-q35 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
ITGA11 integrin, alpha 11 15q22.3-q23 1(0/0/1)
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0)
ITGA1 integrin, alpha 1 5q11.1 1(0/1/0)

Genes from other sources Help(count: 35)

Approved Symbol Approved Name Location Source
PRKCB protein kinase C, beta 16p12 Mapped by significant region
ACTN3 actinin, alpha 3 11q13-q14 Mapped by significant region
FN1 fibronectin 1 2q34 Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 9q22.1 Mapped by significant region
MYLPF myosin light chain, phosphorylatable, fast skeletal muscle 16p11.2 Mapped by CNV
CCND1 cyclin D1 11q13 Mapped by significant region
BAD BCL2-associated agonist of cell death 11q13.1 Mapped by significant region
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 11q13 Mapped by significant region
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 20p12 Mapped by CNV
BCAR1 breast cancer anti-estrogen resistance 1 16q22-q23 Mapped by significant region
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 22q11.21 Mapped by CNV
PDGFD platelet derived growth factor D 11q22.3 Mapped by significant region
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 17q11.2-q12 Mapped by LD-proxy
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2p24 Mapped by significant region
MAPK9 mitogen-activated protein kinase 9 5q35 Mapped by CNV
TNR tenascin R (restrictin, janusin) 1q24 Mapped by significant region
VEGFB vascular endothelial growth factor B 11q13 Mapped by significant region
CAV3 caveolin 3 3p25 Mapped by LD-proxy; Mapped by literature SNP
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
BIRC2 baculoviral IAP repeat containing 2 11q22 Mapped by significant region
BIRC3 baculoviral IAP repeat containing 3 11q22 Mapped by significant region
LAMC2 laminin, gamma 2 1q25-q31 Mapped by significant region
TNN tenascin N 1q23-q24 Mapped by significant region
LAMC1 laminin, gamma 1 (formerly LAMB2) 1q31 Mapped by significant region
LAMA3 laminin, alpha 3 18q11.2 Mapped by significant region
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 Mapped by significant region
TNC tenascin C 9q32-q34 Mapped by significant region
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22 Mapped by CNV
ILK integrin-linked kinase 11p15.4 Mapped by CNV
ARHGAP5 Rho GTPase activating protein 5 14q12 Mapped by significant region
FLT4 fms-related tyrosine kinase 4 5q34-q35 Mapped by CNV
LAMA2 laminin, alpha 2 6q22-q23 Mapped by CNV; Mapped by significant region
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 5q11.2 Mapped by LD-proxy

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014